Antimicrobial and antioxidant activities of coumarins from the roots of Ferulago Campestris (Apiaceae)

Sergio Rosselli, Antonella Maria Maggio, Vivienne Spadaro, Maurizio Bruno, Adriana Basile, Sergio Sorbo, Nicoletta Faraone

Risultato della ricerca: Articlepeer review

127 Citazioni (Scopus)


We report the isolation of several coumarins and the stereochemical assessment of some pyranocoumarins, as well as the antibacterial and antioxidant activities of the three most abundant ones (grandivittin, agasyllin and aegelinol benzoate) isolated from the roots of Ferulago campestris collected in Sicily and of the hydrolysis product (aegelinol). Aegelinol and agasyllin showed antibacterial activity against nine ATCC and the same clinically isolated Gram-positive and Gram-negative bacterial strains. At a concentration between 16 and 125 μg/mL both coumarins showed a significant antibacterial effect against both Gram-negative and Gram-positive bacteria. In particular the ATCC strains Staphylococcus aureus, Salmonella thypii, Enterobacter cloacae and Enterobacter earogenes (MIC = 16 and 32 μg/mL for aegelinol and agasyllin, respectively) were the most inhibited. Antibacterial activity was also found against Helicobacter pylori: a dosedependent inhibition was shown between 5 and 25 μg/mL. The antioxidant activity of the coumarins was evaluated by their effects on human whole blood leukocytes (WB) and on isolated polymorphonucleate (PMN) chemiluminescence (CL), PMA-stimulated and resting.
Lingua originaleEnglish
pagine (da-a)939-952
Numero di pagine14
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1600.1606???
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