Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs)

Natale Belluardo, Pietro Gareri, Angela Trovato-Salinato, Daniele Condorelli, Emilio Russo, Giovambattista De Sarro, Guido Ferreri Ibbadu, Antonella Loiacono, Vincenza Barresi

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Abstract

Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intravenous or intraperitoneal administration of carbenoxolone (5-30 mg/kg) produced a dose-dependent and significant reduction in the clonic and tonic phases of the audiogenic seizures in GEPRs. The anticonvulsant doses were not associated with an impairment of motor coordination. The bilateral microinjection of CBX (0.001-0.50 μg/0.5 μl) into the inferior colliculi, the substantia nigra (pars reticulata or compacta) and the inferior olivary complex was able to reduce the seizure severity score in a dose-dependent manner. The anticonvulsant effects were longer lasting after focal microinjection than after systemic administration. No anticonvulsant effects were observed following focal bilateral microinjections of glycyrrhizin into the same brain areas where CBX was shown to be effective.
Lingua originaleEnglish
pagine (da-a)1205-1216
Numero di pagine12
RivistaNeuropharmacology
Volume47
Stato di pubblicazionePublished - 2004

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cellular and Molecular Neuroscience

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Belluardo, N., Gareri, P., Trovato-Salinato, A., Condorelli, D., Russo, E., De Sarro, G., Ferreri Ibbadu, G., Loiacono, A., & Barresi, V. (2004). Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs). Neuropharmacology, 47, 1205-1216.