Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs)

Natale Belluardo, Guido Ferreri Ibbadu, Antonella Loiacono, Vincenza Barresi, Pietro Gareri, Angela Trovato-Salinato, Daniele Condorelli, Emilio Russo, Giovambattista De Sarro

Risultato della ricerca: Article

55 Citazioni (Scopus)

Abstract

Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intravenous or intraperitoneal administration of carbenoxolone (5-30 mg/kg) produced a dose-dependent and significant reduction in the clonic and tonic phases of the audiogenic seizures in GEPRs. The anticonvulsant doses were not associated with an impairment of motor coordination. The bilateral microinjection of CBX (0.001-0.50 μg/0.5 μl) into the inferior colliculi, the substantia nigra (pars reticulata or compacta) and the inferior olivary complex was able to reduce the seizure severity score in a dose-dependent manner. The anticonvulsant effects were longer lasting after focal microinjection than after systemic administration. No anticonvulsant effects were observed following focal bilateral microinjections of glycyrrhizin into the same brain areas where CBX was shown to be effective.
Lingua originaleEnglish
pagine (da-a)1205-1216
Numero di pagine12
RivistaNeuropharmacology
Volume47
Stato di pubblicazionePublished - 2004

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Carbenoxolone
Anticonvulsants
Epilepsy
Microinjections
Seizures
Glycyrrhetinic Acid
Glycyrrhizic Acid
Inferior Colliculi
Ataxia
Esters
Brain

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cita questo

Belluardo, N., Ferreri Ibbadu, G., Loiacono, A., Barresi, V., Gareri, P., Trovato-Salinato, A., ... De Sarro, G. (2004). Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs). Neuropharmacology, 47, 1205-1216.

Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs). / Belluardo, Natale; Ferreri Ibbadu, Guido; Loiacono, Antonella; Barresi, Vincenza; Gareri, Pietro; Trovato-Salinato, Angela; Condorelli, Daniele; Russo, Emilio; De Sarro, Giovambattista.

In: Neuropharmacology, Vol. 47, 2004, pag. 1205-1216.

Risultato della ricerca: Article

Belluardo, N, Ferreri Ibbadu, G, Loiacono, A, Barresi, V, Gareri, P, Trovato-Salinato, A, Condorelli, D, Russo, E & De Sarro, G 2004, 'Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs)', Neuropharmacology, vol. 47, pagg. 1205-1216.
Belluardo N, Ferreri Ibbadu G, Loiacono A, Barresi V, Gareri P, Trovato-Salinato A e altri. Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs). Neuropharmacology. 2004;47:1205-1216.
Belluardo, Natale ; Ferreri Ibbadu, Guido ; Loiacono, Antonella ; Barresi, Vincenza ; Gareri, Pietro ; Trovato-Salinato, Angela ; Condorelli, Daniele ; Russo, Emilio ; De Sarro, Giovambattista. / Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs). In: Neuropharmacology. 2004 ; Vol. 47. pagg. 1205-1216.
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abstract = "Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intravenous or intraperitoneal administration of carbenoxolone (5-30 mg/kg) produced a dose-dependent and significant reduction in the clonic and tonic phases of the audiogenic seizures in GEPRs. The anticonvulsant doses were not associated with an impairment of motor coordination. The bilateral microinjection of CBX (0.001-0.50 μg/0.5 μl) into the inferior colliculi, the substantia nigra (pars reticulata or compacta) and the inferior olivary complex was able to reduce the seizure severity score in a dose-dependent manner. The anticonvulsant effects were longer lasting after focal microinjection than after systemic administration. No anticonvulsant effects were observed following focal bilateral microinjections of glycyrrhizin into the same brain areas where CBX was shown to be effective.",
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T1 - Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs)

AU - Belluardo, Natale

AU - Ferreri Ibbadu, Guido

AU - Loiacono, Antonella

AU - Barresi, Vincenza

AU - Gareri, Pietro

AU - Trovato-Salinato, Angela

AU - Condorelli, Daniele

AU - Russo, Emilio

AU - De Sarro, Giovambattista

PY - 2004

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N2 - Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intravenous or intraperitoneal administration of carbenoxolone (5-30 mg/kg) produced a dose-dependent and significant reduction in the clonic and tonic phases of the audiogenic seizures in GEPRs. The anticonvulsant doses were not associated with an impairment of motor coordination. The bilateral microinjection of CBX (0.001-0.50 μg/0.5 μl) into the inferior colliculi, the substantia nigra (pars reticulata or compacta) and the inferior olivary complex was able to reduce the seizure severity score in a dose-dependent manner. The anticonvulsant effects were longer lasting after focal microinjection than after systemic administration. No anticonvulsant effects were observed following focal bilateral microinjections of glycyrrhizin into the same brain areas where CBX was shown to be effective.

AB - Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intravenous or intraperitoneal administration of carbenoxolone (5-30 mg/kg) produced a dose-dependent and significant reduction in the clonic and tonic phases of the audiogenic seizures in GEPRs. The anticonvulsant doses were not associated with an impairment of motor coordination. The bilateral microinjection of CBX (0.001-0.50 μg/0.5 μl) into the inferior colliculi, the substantia nigra (pars reticulata or compacta) and the inferior olivary complex was able to reduce the seizure severity score in a dose-dependent manner. The anticonvulsant effects were longer lasting after focal microinjection than after systemic administration. No anticonvulsant effects were observed following focal bilateral microinjections of glycyrrhizin into the same brain areas where CBX was shown to be effective.

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