Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa (Desf.) DC (Apiaceae)

Gabriella Bellone, Antonella Maria Maggio, Sergio Rosselli, Maurizio Bruno, Alessio Alfieri, Adriana Basile, Carla Cicala, Nicola Mascolo, Carmen Formisano

Risultato della ricerca: Article

74 Citazioni (Scopus)

Abstract

The phytochemical investigation of the acetone and methanol extracts of the flowers of Magydaris tomentosa (Desf.) DC afforded six known coumarins as well as (+)-meranzin hydrate (7), not previously reported as a natural product. The antibacterial activity of umbelliprenin (1), osthol (2), imperatorin (3), citropten (4) and (+)-meranzin hydrate (7) was tested against Gram-positive and Gram-negative bacteria. All coumarins (1-7) isolated in this study inhibited growth of all bacterial strains tested (MIC between 16 and 256 μg/mL), the most active being imperatorin (3) (MICs between 32 and 128 μg/mL) and citropten (4) (MICs between 16 and 256 μg/mL). The anticoagulant activity of compounds 1-4 and 7 was also evaluated.
Lingua originaleEnglish
pagine (da-a)116-120
Numero di pagine5
RivistaPlanta Medica
Volume73
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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