Antibacterial activity of flavonoids and phenylpropanoids from Marrubium globosum ssp. libanoticum

Sergio Rosselli, Maurizio Bruno, Adriana Basile, Daniela Rigano, Alfredo Lavitola, Felice Senatore, Carmen Formisano, Anna Basile

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Abstract

Marrubium globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae) is a medicinal plant used for the treatment of inflammatory diseases, asthma, coughs and other pulmonary and urinary problems. The goal of our study was to assess the biological activity of M. globosum testing the methanol extract of aerial parts for its antibacterial activity against bacteria known to cause respiratory, gastrointestinal, skin and urinary disorders; the extract showed antibacterial effects against all the strains of bacteria used. A purification of this active extract showed the presence, as main constituents, of verbascoside, isorhamnetin 3-O-beta-D-rutinoside, quercetin 3-O-beta-D-rutinoside, naringenin 7-O-beta-D-glucoside, kaempferol 3-O-beta-D-rutinoside, isorhamnetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-glucoside, apigenin 7-O-(3''-p-coumaryl)-glucoside, p-methoxy-cinnamic acid, kaempferol 3-O-beta-D-glucoside and apigenin 7-O-beta-D-glucoside. The pure compounds were tested for their antibacterial activity; quercetin 3-O-beta-D-rutinoside, verbascoside and naringenin 7-O-beta-D-glucoside showed the greatest activity
Lingua originaleEnglish
pagine (da-a)395-397
Numero di pagine3
RivistaPhytotherapy Research
Volume21
Stato di pubblicazionePublished - 2007

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All Science Journal Classification (ASJC) codes

  • Pharmacology

Cita questo

Rosselli, S., Bruno, M., Basile, A., Rigano, D., Lavitola, A., Senatore, F., Formisano, C., & Basile, A. (2007). Antibacterial activity of flavonoids and phenylpropanoids from Marrubium globosum ssp. libanoticum. Phytotherapy Research, 21, 395-397.