Antiaging medicine.

•The factors best demonstrated to delay aging are fruit and vegetables, exercise, not smoking, drinking one or two glasses of alcohol daily, and fish consumption.•Vitamin D replacement, in persons with low 25[OH] vitamin D levels, decreases hip fractures, improves muscle strength, enhances function, and decreases mortality.•Antiaging medicine has been hijacked by charlatans who promote unproven or dangerous remedies to a naïve aging public.•Too often animal studies that produce longevity are directly applied to humans before appropriate clinical trials have been carried out.•There is no evidence that hormones or megadoses of vitamins prolong life.•Numerous products of varying quality are available to slow -photoaging and remove skin blemishes.