Anti-adhesion agents against Gram-positive pathogens

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Abstract

The rise of antibiotic-resistance as well as the deficiency of investments by pharmaceutical companies in the development of new antibiotics, have stimulated the investigation of alternative strategies to conventional antibiotics for counteracting the pathogens. A fundamental step of Gram positive pathogenesis is the bacterial adhesion to the host tissue involving a direct and a specific interaction between bacterial surface molecules and host ligands. Targeting the adhesion is a good strategy to design novel anti-infective drugs agents useful to interfere with the pathogenic process and with a virulence mechanism as biofilm formation. This review is focused on anti-virulence compounds which target bacterial surface molecules such as exposed proteins and theicoic acids and on their potential development as therapeutic agents alternative or complementary to conventional antibiotics in the contrast of Gram positive pathogens.The rise of antibiotic-resistance as well as the deficiency of investments by pharmaceutical companies in the development of new antibiotics, have stimulated the investigation of alternative strategies to conventional antibiotics for counteracting the pathogens. A fundamental step of Gram positive pathogenesis is the bacterial adhesion to the host tissue involving a direct and a specific interaction between bacterial surface molecules and host ligands. Targeting the adhesion is a good strategy to design novel anti-infective drugs agents useful to interfere with the pathogenic process and with a virulence mechanism as biofilm formation. This review is focused on anti-virulence compounds which target bacterial surface molecules such as exposed proteins and theicoic acids and on their potential development as therapeutic agents alternative or complementary to conventional antibiotics in the contrast of Gram positive pathogens.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine0
RivistaFuture Microbiology
Volume9
Stato di pubblicazionePublished - 2014

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Anti-Bacterial Agents
Virulence
Bacterial Adhesion
Biofilms
Microbial Drug Resistance
Anti-Infective Agents
Pharmaceutical Preparations
Ligands
Acids
Proteins
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Medicine(all)
  • Microbiology (medical)

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title = "Anti-adhesion agents against Gram-positive pathogens",
abstract = "The rise of antibiotic-resistance as well as the deficiency of investments by pharmaceutical companies in the development of new antibiotics, have stimulated the investigation of alternative strategies to conventional antibiotics for counteracting the pathogens. A fundamental step of Gram positive pathogenesis is the bacterial adhesion to the host tissue involving a direct and a specific interaction between bacterial surface molecules and host ligands. Targeting the adhesion is a good strategy to design novel anti-infective drugs agents useful to interfere with the pathogenic process and with a virulence mechanism as biofilm formation. This review is focused on anti-virulence compounds which target bacterial surface molecules such as exposed proteins and theicoic acids and on their potential development as therapeutic agents alternative or complementary to conventional antibiotics in the contrast of Gram positive pathogens.The rise of antibiotic-resistance as well as the deficiency of investments by pharmaceutical companies in the development of new antibiotics, have stimulated the investigation of alternative strategies to conventional antibiotics for counteracting the pathogens. A fundamental step of Gram positive pathogenesis is the bacterial adhesion to the host tissue involving a direct and a specific interaction between bacterial surface molecules and host ligands. Targeting the adhesion is a good strategy to design novel anti-infective drugs agents useful to interfere with the pathogenic process and with a virulence mechanism as biofilm formation. This review is focused on anti-virulence compounds which target bacterial surface molecules such as exposed proteins and theicoic acids and on their potential development as therapeutic agents alternative or complementary to conventional antibiotics in the contrast of Gram positive pathogens.",
keywords = "Anti-adhesion agents, antivirulence drugs, Gram-positive pathogens",
author = "Domenico Schillaci and Cascioferro, {Stella Maria} and Cusimano, {Maria Grazia}",
year = "2014",
language = "English",
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journal = "Future Microbiology",
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T1 - Anti-adhesion agents against Gram-positive pathogens

AU - Schillaci, Domenico

AU - Cascioferro, Stella Maria

AU - Cusimano, Maria Grazia

PY - 2014

Y1 - 2014

N2 - The rise of antibiotic-resistance as well as the deficiency of investments by pharmaceutical companies in the development of new antibiotics, have stimulated the investigation of alternative strategies to conventional antibiotics for counteracting the pathogens. A fundamental step of Gram positive pathogenesis is the bacterial adhesion to the host tissue involving a direct and a specific interaction between bacterial surface molecules and host ligands. Targeting the adhesion is a good strategy to design novel anti-infective drugs agents useful to interfere with the pathogenic process and with a virulence mechanism as biofilm formation. This review is focused on anti-virulence compounds which target bacterial surface molecules such as exposed proteins and theicoic acids and on their potential development as therapeutic agents alternative or complementary to conventional antibiotics in the contrast of Gram positive pathogens.The rise of antibiotic-resistance as well as the deficiency of investments by pharmaceutical companies in the development of new antibiotics, have stimulated the investigation of alternative strategies to conventional antibiotics for counteracting the pathogens. A fundamental step of Gram positive pathogenesis is the bacterial adhesion to the host tissue involving a direct and a specific interaction between bacterial surface molecules and host ligands. Targeting the adhesion is a good strategy to design novel anti-infective drugs agents useful to interfere with the pathogenic process and with a virulence mechanism as biofilm formation. This review is focused on anti-virulence compounds which target bacterial surface molecules such as exposed proteins and theicoic acids and on their potential development as therapeutic agents alternative or complementary to conventional antibiotics in the contrast of Gram positive pathogens.

AB - The rise of antibiotic-resistance as well as the deficiency of investments by pharmaceutical companies in the development of new antibiotics, have stimulated the investigation of alternative strategies to conventional antibiotics for counteracting the pathogens. A fundamental step of Gram positive pathogenesis is the bacterial adhesion to the host tissue involving a direct and a specific interaction between bacterial surface molecules and host ligands. Targeting the adhesion is a good strategy to design novel anti-infective drugs agents useful to interfere with the pathogenic process and with a virulence mechanism as biofilm formation. This review is focused on anti-virulence compounds which target bacterial surface molecules such as exposed proteins and theicoic acids and on their potential development as therapeutic agents alternative or complementary to conventional antibiotics in the contrast of Gram positive pathogens.The rise of antibiotic-resistance as well as the deficiency of investments by pharmaceutical companies in the development of new antibiotics, have stimulated the investigation of alternative strategies to conventional antibiotics for counteracting the pathogens. A fundamental step of Gram positive pathogenesis is the bacterial adhesion to the host tissue involving a direct and a specific interaction between bacterial surface molecules and host ligands. Targeting the adhesion is a good strategy to design novel anti-infective drugs agents useful to interfere with the pathogenic process and with a virulence mechanism as biofilm formation. This review is focused on anti-virulence compounds which target bacterial surface molecules such as exposed proteins and theicoic acids and on their potential development as therapeutic agents alternative or complementary to conventional antibiotics in the contrast of Gram positive pathogens.

KW - Anti-adhesion agents, antivirulence drugs, Gram-positive pathogens

UR - http://hdl.handle.net/10447/102672

M3 - Article

VL - 9

SP - -

JO - Future Microbiology

JF - Future Microbiology

SN - 1746-0913

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