Another step toward DNA selective targeting: NiII and CuII complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes

Alessio Terenzi, Giampaolo Barone, Christian R. Kowol, Alexander Roller, Alessio Terenzi, Daniela Lötsch, Bernhard K. Keppler, Walter Berger, Sushilla Van Schoonhoven, Giampaolo Barone

Risultato della ricerca: Article

23 Citazioni (Scopus)

Abstract

DNA G-rich sequences are able to form four-stranded structures organized in stacked guanine tetrads. These structures, called G-quadruplexes, were found to have an important role in the regulation of oncogenes expression and became, for such a reason, appealing targets for anticancer drugs. Aiming at finding selective G-quadruplex binders, we have designed, synthesized and characterized a new water soluble Salen-like Schiff base ligand and its NiII and CuII metal complexes. UV-Vis, circular dichroism and FRET measurements indicated that the nickel complex can stabilize oncogene promoter G-quadruplexes with high selectivity, presenting no interactions with duplex DNA at all. The same compound exhibited dose-dependent cytotoxic activity in MCF-7 breast cancer cells when combined with lipofectamine as lipophilic carrier.
Lingua originaleEnglish
pagine (da-a)7758-7767
Numero di pagine10
RivistaDalton Transactions
Volume45
Stato di pubblicazionePublished - 2016

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Schiff Bases
Genes
Ligands
DNA
Coordination Complexes
Guanine
Nickel
Binders
Cells
Water
Pharmaceutical Preparations
disalicylaldehyde ethylenediamine
Lipofectamine

All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry

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Another step toward DNA selective targeting: NiII and CuII complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes. / Terenzi, Alessio; Barone, Giampaolo; Kowol, Christian R.; Roller, Alexander; Terenzi, Alessio; Lötsch, Daniela; Keppler, Bernhard K.; Berger, Walter; Van Schoonhoven, Sushilla; Barone, Giampaolo.

In: Dalton Transactions, Vol. 45, 2016, pag. 7758-7767.

Risultato della ricerca: Article

Terenzi, A, Barone, G, Kowol, CR, Roller, A, Terenzi, A, Lötsch, D, Keppler, BK, Berger, W, Van Schoonhoven, S & Barone, G 2016, 'Another step toward DNA selective targeting: NiII and CuII complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes', Dalton Transactions, vol. 45, pagg. 7758-7767.
Terenzi, Alessio ; Barone, Giampaolo ; Kowol, Christian R. ; Roller, Alexander ; Terenzi, Alessio ; Lötsch, Daniela ; Keppler, Bernhard K. ; Berger, Walter ; Van Schoonhoven, Sushilla ; Barone, Giampaolo. / Another step toward DNA selective targeting: NiII and CuII complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes. In: Dalton Transactions. 2016 ; Vol. 45. pagg. 7758-7767.
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AU - Barone, Giampaolo

AU - Kowol, Christian R.

AU - Roller, Alexander

AU - Terenzi, Alessio

AU - Lötsch, Daniela

AU - Keppler, Bernhard K.

AU - Berger, Walter

AU - Van Schoonhoven, Sushilla

AU - Barone, Giampaolo

PY - 2016

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