Anodal tDCS of the swallowing motor cortex for treatment of dysphagia in multiple sclerosis: a pilot open-label study

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Abstract

Swallowing difficulties are a common symptom of multiple sclerosis (MS). The early detection and treatment of dysphagia is critical to prevent complications, including poor nutrition, dehydration, and lung infections. Recently, transcranial direct current stimulation (tDCS) has been proven to be effective in ameliorating swallowing problems in stroke patients. In this pilot study, we aimed to assess safety and efficacy of transcranial direct current stimulation (tDCS) in the treatment of dysphagia in MS patients. We screened 30 patients by using the 10-item DYsphagia in MUltiple Sclerosis (DYMUS) questionnaire, and patients at risk for dysphagia underwent a clinical and fiberoptic endoscopic evaluation of swallowing (FEES). Six patients who presented with mild to moderate dysphagia underwent the experimental procedures. These consisted of 5 sessions of anodal tDCS applied in consecutive days over the right swallowing motor cortex. Patients were followed-up at 1 week, 1 month and 3 months after treatment, and changes in the Dysphagia Outcome and Severity Scale (DOSS) score between baseline and post-tDCS were assessed. Our results showed that in all patients, the tDCS treatment determined a mild but significant clinical benefit (one-point improvement in the DOSS score) lasting up to 1 month. In conclusion, our preliminary results show that anodal tDCS has therapeutic potential in the treatment of swallowing problems in patients suffering with MS. However, future double-blind, randomized, and sham-controlled studies are needed to confirm the present findings.
Lingua originaleEnglish
pagine (da-a)1471-1473
Numero di pagine3
RivistaNeurological Sciences
Volume39
Stato di pubblicazionePublished - 2018

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Motor Cortex
Deglutition
Deglutition Disorders
Multiple Sclerosis
Therapeutics
Transcranial Direct Current Stimulation
Dehydration
Stroke
Safety
Lung
Infection

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cita questo

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title = "Anodal tDCS of the swallowing motor cortex for treatment of dysphagia in multiple sclerosis: a pilot open-label study",
abstract = "Swallowing difficulties are a common symptom of multiple sclerosis (MS). The early detection and treatment of dysphagia is critical to prevent complications, including poor nutrition, dehydration, and lung infections. Recently, transcranial direct current stimulation (tDCS) has been proven to be effective in ameliorating swallowing problems in stroke patients. In this pilot study, we aimed to assess safety and efficacy of transcranial direct current stimulation (tDCS) in the treatment of dysphagia in MS patients. We screened 30 patients by using the 10-item DYsphagia in MUltiple Sclerosis (DYMUS) questionnaire, and patients at risk for dysphagia underwent a clinical and fiberoptic endoscopic evaluation of swallowing (FEES). Six patients who presented with mild to moderate dysphagia underwent the experimental procedures. These consisted of 5 sessions of anodal tDCS applied in consecutive days over the right swallowing motor cortex. Patients were followed-up at 1 week, 1 month and 3 months after treatment, and changes in the Dysphagia Outcome and Severity Scale (DOSS) score between baseline and post-tDCS were assessed. Our results showed that in all patients, the tDCS treatment determined a mild but significant clinical benefit (one-point improvement in the DOSS score) lasting up to 1 month. In conclusion, our preliminary results show that anodal tDCS has therapeutic potential in the treatment of swallowing problems in patients suffering with MS. However, future double-blind, randomized, and sham-controlled studies are needed to confirm the present findings.",
keywords = "Dysphagia; Motor cortex; Multiple sclerosis; Swallowing; tDCS; Transcranial direct current stimulation; Adult; Deglutition Disorders; Electrodes; Electromyography; Evoked Potentials, Motor; Female; Follow-Up Studies; Humans; Male; Middle Aged; Motor Cortex; Multiple Sclerosis; Pilot Projects; Severity of Illness Index; Transcranial Direct Current Stimulation; Treatment Outcome; 2708; Neurology (clinical); Psychiatry and Mental Health",
author = "Sabrina Realmuto and Rosalia Gargano and Giuseppe Cosentino and Brigida Fierro and Paolo Ragonese and Giuseppe Salemi and Filippo Brighina and Massimo Gangitano and Enrico Alfonsi and Elisa Tocco and Giovanna Bonura",
year = "2018",
language = "English",
volume = "39",
pages = "1471--1473",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia",

}

TY - JOUR

T1 - Anodal tDCS of the swallowing motor cortex for treatment of dysphagia in multiple sclerosis: a pilot open-label study

AU - Realmuto, Sabrina

AU - Gargano, Rosalia

AU - Cosentino, Giuseppe

AU - Fierro, Brigida

AU - Ragonese, Paolo

AU - Salemi, Giuseppe

AU - Brighina, Filippo

AU - Gangitano, Massimo

AU - Alfonsi, Enrico

AU - Tocco, Elisa

AU - Bonura, Giovanna

PY - 2018

Y1 - 2018

N2 - Swallowing difficulties are a common symptom of multiple sclerosis (MS). The early detection and treatment of dysphagia is critical to prevent complications, including poor nutrition, dehydration, and lung infections. Recently, transcranial direct current stimulation (tDCS) has been proven to be effective in ameliorating swallowing problems in stroke patients. In this pilot study, we aimed to assess safety and efficacy of transcranial direct current stimulation (tDCS) in the treatment of dysphagia in MS patients. We screened 30 patients by using the 10-item DYsphagia in MUltiple Sclerosis (DYMUS) questionnaire, and patients at risk for dysphagia underwent a clinical and fiberoptic endoscopic evaluation of swallowing (FEES). Six patients who presented with mild to moderate dysphagia underwent the experimental procedures. These consisted of 5 sessions of anodal tDCS applied in consecutive days over the right swallowing motor cortex. Patients were followed-up at 1 week, 1 month and 3 months after treatment, and changes in the Dysphagia Outcome and Severity Scale (DOSS) score between baseline and post-tDCS were assessed. Our results showed that in all patients, the tDCS treatment determined a mild but significant clinical benefit (one-point improvement in the DOSS score) lasting up to 1 month. In conclusion, our preliminary results show that anodal tDCS has therapeutic potential in the treatment of swallowing problems in patients suffering with MS. However, future double-blind, randomized, and sham-controlled studies are needed to confirm the present findings.

AB - Swallowing difficulties are a common symptom of multiple sclerosis (MS). The early detection and treatment of dysphagia is critical to prevent complications, including poor nutrition, dehydration, and lung infections. Recently, transcranial direct current stimulation (tDCS) has been proven to be effective in ameliorating swallowing problems in stroke patients. In this pilot study, we aimed to assess safety and efficacy of transcranial direct current stimulation (tDCS) in the treatment of dysphagia in MS patients. We screened 30 patients by using the 10-item DYsphagia in MUltiple Sclerosis (DYMUS) questionnaire, and patients at risk for dysphagia underwent a clinical and fiberoptic endoscopic evaluation of swallowing (FEES). Six patients who presented with mild to moderate dysphagia underwent the experimental procedures. These consisted of 5 sessions of anodal tDCS applied in consecutive days over the right swallowing motor cortex. Patients were followed-up at 1 week, 1 month and 3 months after treatment, and changes in the Dysphagia Outcome and Severity Scale (DOSS) score between baseline and post-tDCS were assessed. Our results showed that in all patients, the tDCS treatment determined a mild but significant clinical benefit (one-point improvement in the DOSS score) lasting up to 1 month. In conclusion, our preliminary results show that anodal tDCS has therapeutic potential in the treatment of swallowing problems in patients suffering with MS. However, future double-blind, randomized, and sham-controlled studies are needed to confirm the present findings.

KW - Dysphagia; Motor cortex; Multiple sclerosis; Swallowing; tDCS; Transcranial direct current stimulation; Adult; Deglutition Disorders; Electrodes; Electromyography; Evoked Potentials

KW - Motor; Female; Follow-Up Studies; Humans; Male; Middle Aged; Motor Cortex; Multiple Sclerosis; Pilot Projects; Severity of Illness Index; Transcranial Direct Current Stimulation; Treatment Outcome; 2708; Neurology (clinical); Psychiatry and Mental Health

UR - http://hdl.handle.net/10447/340078

M3 - Article

VL - 39

SP - 1471

EP - 1473

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

ER -