ANMCO/ELAS/SIBioC Consensus Document: Biomarkers in heart failure

Marcello Ciaccio, Serge Masson, Marco Migliardi, Alberto Aimo, Claudio Passino, Michele Massimo Gulizia, Roberto Latini, Giuseppe Di Tano, Michele Massimo Gulizia, Nadia Aspromonte, Massimo Iacoviello, Gianfranco Misuraca, Marco Migliardi, Roberto Latini, Michele Emdin, Andrea Mortara, Mauro Feola, Roberto Valle, Aldo Clerico

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5 Citazioni (Scopus)


Biomarkers have dramatically impacted the way heart failure (HF) patients are evaluated and managed. A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological or pathogenic processes, or pharmacological responses to a therapeutic intervention. Natriuretic peptides [B-type natriuretic peptide (BNP) and N-terminal proBNP] are the gold standard biomarkers in determining the diagnosis and prognosis of HF, and a natriuretic peptide-guided HF management looks promising. In the last few years, an array of additional biomarkers has emerged, each reflecting different pathophysiological processes in the development and progression of HF: myocardial insult, inflammation, fibrosis, and remodelling, but their role in the clinical care of the patient is still partially defined and more studies are needed before to be well validated. Moreover, several new biomarkers have the potential to identify patients with early renal dysfunction and appear to have promise to help the management cardio-renal syndrome. With different biomarkers reflecting HF presence, the various pathways involved in its progression, as well as identifying unique treatment options for HF management, a closer cardiologist-laboratory link, with a multi-biomarker approach to the HF patient, is not far ahead, allowing the unique opportunity for specifically tailoring care to the individual pathological phenotype.
Lingua originaleEnglish
pagine (da-a)D102-D112
Numero di pagine11
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Ciaccio, M., Masson, S., Migliardi, M., Aimo, A., Passino, C., Gulizia, M. M., Latini, R., Di Tano, G., Gulizia, M. M., Aspromonte, N., Iacoviello, M., Misuraca, G., Migliardi, M., Latini, R., Emdin, M., Mortara, A., Feola, M., Valle, R., & Clerico, A. (2017). ANMCO/ELAS/SIBioC Consensus Document: Biomarkers in heart failure. EUROPEAN HEART JOURNAL SUPPLEMENTS, 19, D102-D112.