Anidulafungin in combination with amphotericin B against Aspergillus fumigatus.

Maria Eleonora Milici, Eleonora Pisa, Francesco Barchiesi, Eleonora Pisa, Eleonora Pisa, Cristian Loretelli, Elisabetta Spreghini, Alfredo Santinelli, Fiorenza Orlando, Esther Manso, Giorgio Scalise

    Risultato della ricerca: Articlepeer review

    15 Citazioni (Scopus)

    Abstract

    We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.
    Lingua originaleEnglish
    pagine (da-a)4035-4039
    Numero di pagine5
    RivistaAntimicrobial Agents and Chemotherapy
    Volume53
    Stato di pubblicazionePublished - 2009

    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Pharmacology (medical)
    • Infectious Diseases

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