Anidulafungin in combination with amphotericin B against Aspergillus fumigatus.

Maria Eleonora Milici, Eleonora Pisa, Francesco Barchiesi, Eleonora Pisa, Eleonora Pisa, Eleonora Pisa, Cristian Loretelli, Elisabetta Spreghini, Alfredo Santinelli, Fiorenza Orlando, Esther Manso, Giorgio Scalise

    Risultato della ricerca: Articlepeer review

    15 Citazioni (Scopus)

    Abstract

    We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.
    Lingua originaleEnglish
    pagine (da-a)4035-4039
    Numero di pagine5
    RivistaAntimicrobial Agents and Chemotherapy
    Volume53
    Stato di pubblicazionePublished - 2009

    All Science Journal Classification (ASJC) codes

    • ???subjectarea.asjc.3000.3004???
    • ???subjectarea.asjc.2700.2736???
    • ???subjectarea.asjc.2700.2725???

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