Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia.

Claudio Tripodo, Carla Guarnotta, Elisa Sozzi, Rossana Maffei, Silvia Martinelli, Rita Santachiara, Gian Matteo Rigolin, Stefania Fiorcari, Valeria Coluccio, Ilaria Castelli, Gianluca Gaidano, Francesco Forconi, Antonella Zucchetto, Patrizia Zucchini, Giovanni Del Poeta, Roberto Marasca, Valter Gattei, Giovanna Leonardi, Antonio Cuneo, Giuseppe TorelliDavide Rossi, Marcella Fontana

Risultato della ricerca: Articlepeer review

45 Citazioni (Scopus)

Abstract

The clinical relevance of angiopoietin-2 (Ang2) in chronic lymphocytic leukemia (CLL) was previously suggested by the association between high Ang2, and shorter progression-free survival reported in small series of patients. Here, we evaluated Ang2 glycoprotein levels in plasma samples collected from a multicentric cohort of CLL patients (n = 316) using an enzyme-linked immunosorbent assay method, and we investigated its prognostic role in relation to time to first treatment (TTFT) and overall survival. Based on a cutoff equal to 2459 pg/mL, we divided our cohort in 2 subsets (high and low Ang2) composing 100 (31.6%) and 216 (68.4%) patients, respectively. High Ang2 was predictive of reduced TTFT (P < .001) and overall survival (P = .002). Multivariate analysis confirmed that high Ang2 was an independent prognosticator for TTFT (hazard ratio = 1.739; 95% confidence interval, 1.059-2.857; P = .029). Significant associations were found between high Ang2 and advanced Binet stages (P < .001), high beta(2)-microglobulin (P < .001), unmutated variable region of immunoglobulin heavy chain gene status (P < .001), high CD38 and zeta-chain-associated protein kinase 70 expression (P < .001 and P = .003), and intermediate/high cytogenetic risk (P = .005). Moreover, Ang2 added prognostic power to other conventional prognosticators and helped to refine prognosis among CLL subsets with both high and low vascular endothelial growth factor plasma levels. Ang2 plasma level may be a useful independent prognosticator for CLL.
Lingua originaleEnglish
pagine (da-a)584-592
Numero di pagine9
RivistaBlood
Volume4
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Fingerprint Entra nei temi di ricerca di 'Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia.'. Insieme formano una fingerprint unica.

Cita questo