Background: We have recently reported that the susceptibility for Mediterraneanspotted fever (MSF) caused by Rickettsia conorii, is influenced by the Th2 and Th1cytokine genetic polymorphism profiles. Less it is known on the effect of genepolymorphisms of cytokine produced by the Th17. Methods: 70 Sicilian patientsaffected by MSF and 239 control subjects matched for age, gender, and geographicorigin were typed for functionally relevant single nucleotide polymorphisms (SNPs) ofIFN-γ (+874 T/A), IL-18 (-137 G/C and -607A/C ) and IL-17 (7488T/C) according toour laboratory procedures. Results: No significant differences in IL-18 -137 G/C,-607A/C and in IFN-γ +874 T /A genotype frequencies were observed. On thecontrary a statistically significant (p value= 0.0126) increase of the IL-17 TTgenotype frequency of in MSF was observed. Conclusions: Cytokines play a crucialrole in modulation of the host defense and genetically determined differences incytokine production seem to influence the extent and severity of a large number ofinfectious diseases. 7488T/C SNP impinge on IL-17 signaling and might play acrucial role in neutrophil recruitment, induction of IFN-γ and IL-12 production inmacrophages and in the induction of T regulatory cells. Our results suggest that agenetically determined increase of IL-17 dependent activation pathways mightinterfere with R. Conorii infection control.
|Numero di pagine||1|
|Stato di pubblicazione||Published - 2012|