Analysis of the LRP10 gene in patients with Parkinson's disease and dementia with Lewy bodies from Southern Italy

Marco D'Amelio, Maurizio Morelli, Monica Gagliardi, Radha Procopio, Giuseppe Nicoletti, Grazia Annesi, Aldo Quattrone

Risultato della ricerca: Articlepeer review

Abstract

Recently, the LRP10 gene has been associated with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), anddementia with Lewy bodies (DLB). The aim of the present study was to evaluate the presence of mutations of the LRP10 gene inpatients with PD or DLB from Southern Italy. Sequencing analysis revealed only 2 missense and 3 synonymous variants inpatients and control subjects and a rare variant p.L622F in a PD case. These results suggest that LRP10 mutations are not afrequent cause of PD and DLB in Southern Italy.
Lingua originaleEnglish
Numero di pagine4
RivistaNeurological Sciences
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cita questo