Analysis of the LRP10 gene in patients with Parkinson's disease and dementia with Lewy bodies from Southern Italy

Marco D'Amelio; Maurizio Morelli; Monica Gagliardi; Radha Procopio; Giuseppe Nicoletti; Grazia Annesi; Aldo Quattrone

Analysis of the LRP10 gene in patients with Parkinson's disease and dementia with Lewy bodies from Southern Italy

Marco D'Amelio, Maurizio Morelli, Monica Gagliardi, Radha Procopio, Giuseppe Nicoletti, Grazia Annesi, Aldo Quattrone

Biomedicina, Neuroscienze e Diagnostica avanzata

Risultato della ricerca: Article › peer review

Abstract

Recently, the LRP10 gene has been associated with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), anddementia with Lewy bodies (DLB). The aim of the present study was to evaluate the presence of mutations of the LRP10 gene inpatients with PD or DLB from Southern Italy. Sequencing analysis revealed only 2 missense and 3 synonymous variants inpatients and control subjects and a rare variant p.L622F in a PD case. These results suggest that LRP10 mutations are not afrequent cause of PD and DLB in Southern Italy.

Lingua originale	English
Numero di pagine	4
Rivista	Neurological Sciences
Stato di pubblicazione	Published - 2020

All Science Journal Classification (ASJC) codes

Dermatology
Clinical Neurology
Psychiatry and Mental health

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title = "Analysis of the LRP10 gene in patients with Parkinson's disease and dementia with Lewy bodies from Southern Italy",

abstract = "Recently, the LRP10 gene has been associated with Parkinson{\textquoteright}s disease (PD), Parkinson{\textquoteright}s disease with dementia (PDD), anddementia with Lewy bodies (DLB). The aim of the present study was to evaluate the presence of mutations of the LRP10 gene inpatients with PD or DLB from Southern Italy. Sequencing analysis revealed only 2 missense and 3 synonymous variants inpatients and control subjects and a rare variant p.L622F in a PD case. These results suggest that LRP10 mutations are not afrequent cause of PD and DLB in Southern Italy.",

author = "Marco D'Amelio and Maurizio Morelli and Monica Gagliardi and Radha Procopio and Giuseppe Nicoletti and Grazia Annesi and Aldo Quattrone",

year = "2020",

language = "English",

journal = "Neurological Sciences",

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T1 - Analysis of the LRP10 gene in patients with Parkinson's disease and dementia with Lewy bodies from Southern Italy

AU - D'Amelio, Marco

AU - Morelli, Maurizio

AU - Gagliardi, Monica

AU - Procopio, Radha

AU - Nicoletti, Giuseppe

AU - Annesi, Grazia

AU - Quattrone, Aldo

PY - 2020

Y1 - 2020

N2 - Recently, the LRP10 gene has been associated with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), anddementia with Lewy bodies (DLB). The aim of the present study was to evaluate the presence of mutations of the LRP10 gene inpatients with PD or DLB from Southern Italy. Sequencing analysis revealed only 2 missense and 3 synonymous variants inpatients and control subjects and a rare variant p.L622F in a PD case. These results suggest that LRP10 mutations are not afrequent cause of PD and DLB in Southern Italy.

AB - Recently, the LRP10 gene has been associated with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), anddementia with Lewy bodies (DLB). The aim of the present study was to evaluate the presence of mutations of the LRP10 gene inpatients with PD or DLB from Southern Italy. Sequencing analysis revealed only 2 missense and 3 synonymous variants inpatients and control subjects and a rare variant p.L622F in a PD case. These results suggest that LRP10 mutations are not afrequent cause of PD and DLB in Southern Italy.

UR - http://hdl.handle.net/10447/437098

M3 - Article

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

ER -