TY - JOUR
T1 - Analysis of N-terminal pro-B-type natriuretic peptide in patients with acute coronary syndromes.
AU - Vitale, Francesco
AU - Corrado, Egle
AU - Novo, Giuseppina
AU - Assennato, Pasquale
AU - Novo, Salvatore
AU - Hoffmann, Enrico
AU - Amoroso, Gisella
AU - Augugliaro, Stefano
AU - Mulè, Maria Cristina
AU - Novo, Salvatore
AU - Coppola, Giuseppe
AU - Novo, Giuseppina
AU - Assennato, Pasquale
AU - Hoffmann, Enrico
AU - Corrado, Egle
AU - Cucchiara, Angela
AU - Amoroso, Gisella Rita
AU - Coppola, Giuseppe
AU - Mule', Maria Cristina
AU - Augugliaro, Stefano
PY - 2009
Y1 - 2009
N2 - BACKGROUND: The N-terminal portion of brain natriuretic peptide (NT-proBNP) has been identified as an indicator of prognosis in different cardiovascular diseases. The objective of this study was to determine the utility of measuring plasma NT-proBNP levels in patients with acute coronary syndromes. METHODS AND RESULTS: We studied 66 patients admitted in our division for acute coronary syndromes. Patients underwent a venous blood sample within 24 h from the admission to determine NT-proBNP levels. Increasing plasma levels of NT-proBNP (in tertiles) was associated with a greater history of hypertension and current smoking, whereas biochemical parameters were associated with higher level of creatine kinase-MB mass, cardiac troponin I, and renal insufficiency. We detected correlations between the values of NT-proBNP and several variables; positive correlations were found between the values of NT-proBNP and creatinine (r=+0354; P=0.0024), cardiac troponin I levels (r=0320; P=0.0111), and creatine kinase-MB mass values (r=0261; P=0.035). An interesting result of our study was a significantly longer hospitalization in those patients belonging to the third tertile compared with those belonging to the first one (P=0.02). Finally, we showed a higher N-terminal brain natriuretic peptide level in patients with poor outcome during the hospitalization (left-ventricular systolic dysfunction, recurrent ischemic events, or death) compared with those who did not (3204+/-1841 vs. 836+/-1136, P=0.003). CONCLUSION: Measurement of B-type natriuretic peptide provides predictive information during the hospitalization in patients with acute coronary syndromes.
AB - BACKGROUND: The N-terminal portion of brain natriuretic peptide (NT-proBNP) has been identified as an indicator of prognosis in different cardiovascular diseases. The objective of this study was to determine the utility of measuring plasma NT-proBNP levels in patients with acute coronary syndromes. METHODS AND RESULTS: We studied 66 patients admitted in our division for acute coronary syndromes. Patients underwent a venous blood sample within 24 h from the admission to determine NT-proBNP levels. Increasing plasma levels of NT-proBNP (in tertiles) was associated with a greater history of hypertension and current smoking, whereas biochemical parameters were associated with higher level of creatine kinase-MB mass, cardiac troponin I, and renal insufficiency. We detected correlations between the values of NT-proBNP and several variables; positive correlations were found between the values of NT-proBNP and creatinine (r=+0354; P=0.0024), cardiac troponin I levels (r=0320; P=0.0111), and creatine kinase-MB mass values (r=0261; P=0.035). An interesting result of our study was a significantly longer hospitalization in those patients belonging to the third tertile compared with those belonging to the first one (P=0.02). Finally, we showed a higher N-terminal brain natriuretic peptide level in patients with poor outcome during the hospitalization (left-ventricular systolic dysfunction, recurrent ischemic events, or death) compared with those who did not (3204+/-1841 vs. 836+/-1136, P=0.003). CONCLUSION: Measurement of B-type natriuretic peptide provides predictive information during the hospitalization in patients with acute coronary syndromes.
KW - N-terminal pro-B-type natriuretic peptide
KW - Nt-proBNP
KW - acute coronary sydrome
KW - N-terminal pro-B-type natriuretic peptide
KW - Nt-proBNP
KW - acute coronary sydrome
UR - http://hdl.handle.net/10447/44210
M3 - Article
VL - 20
SP - 225
EP - 229
JO - Coronary Artery Disease
JF - Coronary Artery Disease
SN - 0954-6928
ER -