Infection risk, sepsis and mortality after severe burn are primarily determined by patientage, burn size, and depth. Whether genetic differences contribute to otherwise unexpectedvariability in outcomes is unknown. We sought to determine whether there was anassociation between IL-6, IL-10 and IL-17 polymorphisms with cytokine production anddevelopment of sepsis.We evaluated 71 patients with burns 15% TBSA and 109 healthy subjects. The genotypesof IL-6 ( 174C/G), IL-10 ( 819C/T and 1082A/G) and IL-17 (7488T/C) polymorphisms wereidentified applying polymerase chain reaction protocols. The cytokine levels in serum weredetermined with enzyme-linked immunoabsorbent assays.Our results demonstrated no significant differences in the genotype frequencies studiedbetween burn patients and healthy subjects. No significant associations were found amongIL-6 and IL-17F genotypes and the related cytokine serum levels. Only IL-10 promoter 1082GG genotype was related to an increased IL-10 production in burned patients. Inaddition, septic subjects bearing 1082G/G genotype have shown the highest and non-septicbearing 1082A/* genotypes the lowest IL-10 serum levels. All together these data seem toindicate that genetically determined individual difference in IL-10 production might influencethe susceptibility to septic complications in burned patients and suggest that thesemarkers might be useful in burned patient management.
|Numero di pagine||6|
|Stato di pubblicazione||Published - 2012|