Analysis of β2-agonists in cattle hair samples using a rapid UHPLC–ESI–MS/MS method

Vita Di Stefano; Vincenzo Ferrantelli; Nicola Cicero; Andrea Macaluso; Angelina Alongi; Vita Giaccone; Rosa Pitonzo

Analysis of β2-agonists in cattle hair samples using a rapid UHPLC–ESI–MS/MS method

Vita Di Stefano, Vincenzo Ferrantelli, Nicola Cicero, Andrea Macaluso, Angelina Alongi, Vita Giaccone, Rosa Pitonzo

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

2 Citazioni (Scopus)

Abstract

A simple and efficient method was developed for simultaneousanalysis of five illegal residual β2-agonists in cattle hair. β2-Agonistswere quantified by ultra high performance liquid chromatographycoupled with electrospray ionisation tandem mass spectrometryoperating in positive multiple-reaction monitoring mode. The methodwas validated as quantitative confirmatory method according to theEU Decision 2002/657/EC: instrumental linearity, specificity, precision,recovery, decision limit (CCα) and detection capability (CCβ) wereevaluated. The recovery were greater than 90% and the methodappeared suitable for the control of these β2-agonists in cattle hairsamples with LOQ values between 4.9 and 5.5 μg/kg. This methodcould represent a simple and cheap approach to confirm β2-agonistscontamination of cattle for feeding in a not invasive way and beforeslaughter operations.

Lingua originale	English
Numero di pagine	5
Rivista	Natural Product Research
Stato di pubblicazione	Published - 2016

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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title = "Analysis of β2-agonists in cattle hair samples using a rapid UHPLC–ESI–MS/MS method",

abstract = "A simple and efficient method was developed for simultaneousanalysis of five illegal residual β2-agonists in cattle hair. β2-Agonistswere quantified by ultra high performance liquid chromatographycoupled with electrospray ionisation tandem mass spectrometryoperating in positive multiple-reaction monitoring mode. The methodwas validated as quantitative confirmatory method according to theEU Decision 2002/657/EC: instrumental linearity, specificity, precision,recovery, decision limit (CCα) and detection capability (CCβ) wereevaluated. The recovery were greater than 90% and the methodappeared suitable for the control of these β2-agonists in cattle hairsamples with LOQ values between 4.9 and 5.5 μg/kg. This methodcould represent a simple and cheap approach to confirm β2-agonistscontamination of cattle for feeding in a not invasive way and beforeslaughter operations.",

author = "{Di Stefano}, Vita and Vincenzo Ferrantelli and Nicola Cicero and Andrea Macaluso and Angelina Alongi and Vita Giaccone and Rosa Pitonzo",

year = "2016",

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journal = "Natural Product Research",

issn = "1478-6419",

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T1 - Analysis of β2-agonists in cattle hair samples using a rapid UHPLC–ESI–MS/MS method

AU - Di Stefano, Vita

AU - Ferrantelli, Vincenzo

AU - Cicero, Nicola

AU - Macaluso, Andrea

AU - Alongi, Angelina

AU - Giaccone, Vita

AU - Pitonzo, Rosa

PY - 2016

Y1 - 2016

N2 - A simple and efficient method was developed for simultaneousanalysis of five illegal residual β2-agonists in cattle hair. β2-Agonistswere quantified by ultra high performance liquid chromatographycoupled with electrospray ionisation tandem mass spectrometryoperating in positive multiple-reaction monitoring mode. The methodwas validated as quantitative confirmatory method according to theEU Decision 2002/657/EC: instrumental linearity, specificity, precision,recovery, decision limit (CCα) and detection capability (CCβ) wereevaluated. The recovery were greater than 90% and the methodappeared suitable for the control of these β2-agonists in cattle hairsamples with LOQ values between 4.9 and 5.5 μg/kg. This methodcould represent a simple and cheap approach to confirm β2-agonistscontamination of cattle for feeding in a not invasive way and beforeslaughter operations.

AB - A simple and efficient method was developed for simultaneousanalysis of five illegal residual β2-agonists in cattle hair. β2-Agonistswere quantified by ultra high performance liquid chromatographycoupled with electrospray ionisation tandem mass spectrometryoperating in positive multiple-reaction monitoring mode. The methodwas validated as quantitative confirmatory method according to theEU Decision 2002/657/EC: instrumental linearity, specificity, precision,recovery, decision limit (CCα) and detection capability (CCβ) wereevaluated. The recovery were greater than 90% and the methodappeared suitable for the control of these β2-agonists in cattle hairsamples with LOQ values between 4.9 and 5.5 μg/kg. This methodcould represent a simple and cheap approach to confirm β2-agonistscontamination of cattle for feeding in a not invasive way and beforeslaughter operations.

UR - http://hdl.handle.net/10447/213269

M3 - Article

JO - Natural Product Research

JF - Natural Product Research

SN - 1478-6419

ER -