Analgesic effects of nonsteroidal anti-inflammatory drugs in cancer pain due to somatic or visceral mechanisms

Alessandra Casuccio, Sebastiano Mercadante, Jafar Kargar, Salvatore Pumo, Antonio Agnello, Serena Garofalo

Risultato della ricerca: Article

44 Citazioni (Scopus)

Abstract

The role of nonsteroidal anti-inflammatory drugs (NSAIDs) is well established in the treatment of cancer pain. This class of drugs is considered particularly effective in pain due to somatic mechanisms, although proof of this observation is lacking. To ascertain whether NSAIDs are more effective in specific nociceptive forms of cancer pain, they were administered alone or added to opioids in 32 patients with a sole pain mechanism, somatic pain due to bone metastases (17 patients) or visceral pain (15 patients), respectively. Pain intensity between the two groups were observed. However, patients with a visceral mechanisms required higher opioid doses after a week of treatment. No differences in adverse effects were reported. NSAIDs may be useful drugs in the management of cancer pain, regardless of the mechanism of pain involved. The incidence of adverse effects during prolonged administration should be assessed in future studies.
Lingua originaleEnglish
pagine (da-a)351-356
Numero di pagine6
RivistaJournal of Pain and Symptom Management
Volume17
Stato di pubblicazionePublished - 1999

All Science Journal Classification (ASJC) codes

  • Nursing(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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