An Unusual Presentation of Zollinger-Ellison Syndrome

Mario Cottone, Marco Messina

Risultato della ricerca: Article

Abstract

Abstract Zollinger-Ellison syndrome is an often progressive, persistent and frequently life-threatening disease, described for the first time as characterized by ulceration of the upper jejunum, hypersecretion of gastric acid and non-beta islet cell tumors of the pancreas; this syndrome is due to the hypersecretion of gastrin. We report a case of Zollinger-Ellison syndrome presenting as severe esophagitis evolving in stenosis, which demonstrates how a delayed diagnosis may induce risk of disease spreading. In this setting new diagnostic approaches, such as somatostatin receptor scanning and positron emission tomography with 68 Ga-labeled octreotide, could be particularly useful, as well as further new therapeutic options, such as molecular targeted treatments and peptide receptor radionuclide therapy, though surgery is currently the only form of curative treatment, and the role of the therapeutic options mentioned needs to be clarified by forthcoming studies
Lingua originaleEnglish
pagine (da-a)1-6
Numero di pagine6
RivistaCase Reports in Gastroenterology
Volume7
Stato di pubblicazionePublished - 2013

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Zollinger-Ellison Syndrome
Islet Cell Adenoma
Therapeutics
Somatostatin Receptors
Octreotide
Peptide Receptors
Esophagitis
Delayed Diagnosis
Gastric Acid
Gastrins
Jejunum
Radioisotopes
Positron-Emission Tomography
Pancreas
Pathologic Constriction

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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An Unusual Presentation of Zollinger-Ellison Syndrome. / Cottone, Mario; Messina, Marco.

In: Case Reports in Gastroenterology, Vol. 7, 2013, pag. 1-6.

Risultato della ricerca: Article

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AB - Abstract Zollinger-Ellison syndrome is an often progressive, persistent and frequently life-threatening disease, described for the first time as characterized by ulceration of the upper jejunum, hypersecretion of gastric acid and non-beta islet cell tumors of the pancreas; this syndrome is due to the hypersecretion of gastrin. We report a case of Zollinger-Ellison syndrome presenting as severe esophagitis evolving in stenosis, which demonstrates how a delayed diagnosis may induce risk of disease spreading. In this setting new diagnostic approaches, such as somatostatin receptor scanning and positron emission tomography with 68 Ga-labeled octreotide, could be particularly useful, as well as further new therapeutic options, such as molecular targeted treatments and peptide receptor radionuclide therapy, though surgery is currently the only form of curative treatment, and the role of the therapeutic options mentioned needs to be clarified by forthcoming studies

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