An unusual fatal case of overdose of Vinblastine and review of literature

Elvira Ventura Spagnolo, Francesca Indorato, Cataldo Raffino, Cristina Mondello, Luigi Cardia, Giovanni Bartoloni, Giulio Cardia, Cristina Mondello, Francesca Indorato

Risultato della ricerca: Articlepeer review

2 Citazioni (Scopus)

Abstract

The pharmacological treatment of neoplasia is based on the use of chemotherapeutic substances. Chemotherapeutic agents can cause acute and chronic toxicity even at therapeutic doses. For this reason their overdose puts a patientâs life at severe risk. This work presents an unusual fatal case of overdose subsequent to an accidental massive administration of Vinblastine (90 mg instead of 9 mg), slow bolus (five minutes), to a 33-year-old woman who suffered from Hodgkinâs Lymphoma. The administration of the massive dose was due to a transcription error of the therapeutic treatment plan and miscommunication between the health professionals which caused the use of the wrong dose. The forensic investigation showed the systemic macroscopic and histological changes due to the toxic effect of Vinblastine on the body, by offering a realistic example of the microscopic tissue changes caused by the antineoplastic agent to different organs. Such evidence shows the importance of being very accurate when writing the therapeutic treatment plans and of counting on adequately-trained health care staff.
Lingua originaleEnglish
pagine (da-a)704-710
Numero di pagine7
RivistaTHE AUSTRALIAN JOURNAL OF FORENSIC SCIENCES
Volume49
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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