An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds

Risultato della ricerca: Articlepeer review

27 Citazioni (Scopus)

Abstract

The synthesis, the antitumor activity, the SAR and, whenever described, the possible mode of action of 1,2,4-triazine derivatives, their N-oxides, N,. N'-dioxides as well as the benzo- and hetero-fused systems are reported. Herein are treated derivatives disclosed to literature from the beginning of this century up to 2016. Among the three possible triazine isomers, 1,2,4-triazines are the most studied ones and many derivatives having remarkable antitumor activity have been reported in the literature and also patented reaching advanced phases of clinical trials.
Lingua originaleEnglish
pagine (da-a)328-375
Numero di pagine48
RivistaEuropean Journal of Medicinal Chemistry
Volume142
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1600.1605???

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