An efficient synthesis of pyrrolo[3',2':4,5]thiopyrano[3,2-b]pyridin-2-one:a new ring system of pharmaceutical interest

Risultato della ricerca: Articlepeer review

25 Citazioni (Scopus)

Abstract

series of pyrrolo[3',2':4,5]thiopyrano[3,2-b]pyridin-2-ones 4 was prepared in good yields by reacting enaminoketones with cyanomethylene active compounds such as phenylsulfonylacetonitrile, benzoylacetonitrile, and malononitrile. Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda against a panel of about 60 human tumor cell lines, and one of them showed inhibitory activity against all cancer cell lines reaching on 48% of them GI50 values at submicromolar leveland on the majority of the remaining ones in the low micromolar concentration.
Lingua originaleEnglish
pagine (da-a)5087-5094
Numero di pagine8
RivistaTETRAHEDRON
Volume68
Stato di pubblicazionePublished - 2012

Fingerprint Entra nei temi di ricerca di 'An efficient synthesis of pyrrolo[3',2':4,5]thiopyrano[3,2-b]pyridin-2-one:a new ring system of pharmaceutical interest'. Insieme formano una fingerprint unica.

Cita questo