Giovanni Tomasello, Francesco Cappello, Francesco Carini, Dario Raimondo, Giancarlo Pompei, Provvidenza Damiani, Aroldo Gabriele Rizzo, Emanuele Sinagra, Georgios Amvrosiadis, Marco Ciofalo, Gaetano Cristian Morreale, Giuseppe Mastrocinque, Carmelinda Canale, Dario Raimondo, Giovanni Tomasello, Dario Raimondo, Francesco Cappello

Risultato della ricerca: Articlepeer review


Inflammatory Bowel Disease (IBD), which includes both Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic idiopathic inflammatory disorder affecting the gastrointestinal tract. Extraintestinal manifestations (EIM) are common in patients with IBD, and occur in 6-47% of patients with CD or UC. EIM can involve organs other than the gastrointestinal tract such as skin, eyes, joints, biliary tract and kidneis. Renal and urinary involvement particularly occurs in 4-23% of patients with IBD. Among the renal complications of IBD, seconfary amyloidosis (AA-type, AAA) is a rare but serious complication. renal amyloidosis has been proven to be the most common lethal manifestation of IBD-associated amyloidosis, since renal involvement rapidly leads to end-stage renal failure. A few studies suggest that AAA is more prevalent in CD than in UC, mainly occurring in male patients with an extensive long-lasting and penetrating ddisease pattern. The therapeutic approaches of IBD-associated AAA are based both on control of the chronic inflammatory process that causes the production and storage of serum amyloid A (SAA), which is a precursor of the amyloid, as well as on destabilizing amyloid fibrils so that they can no longer maintain their pleated sheet configuration; however, in patients with end-stage renal disease, the only therapeutic options still available are hemodyalisis and renal transplantation. Whether effective treatment exists for AAA remain controversial.
Lingua originaleEnglish
pagine (da-a)5-13
Numero di pagine9
RivistaProgress in Nutrition
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1100.1106???
  • ???subjectarea.asjc.2900.2916???


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