AMYLOIDOSIS AND INFLAMMATORY BOWEL DISEASE: FACT OR MITH?

Francesco Carini, Giovanni Tomasello, Francesco Cappello, Dario Raimondo, Giancarlo Pompei, Aroldo Gabriele Rizzo, Emanuele Sinagra, Georgios Amvrosiadis, Gaetano Cristian Morreale, Carmelinda Canale, Giovanni Tomasello, Francesco Cappello

Risultato della ricerca: Article

Abstract

Inflammatory Bowel Disease (IBD), which includes both Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic idiopathic inflammatory disorder affecting the gastrointestinal tract. Extraintestinal manifestations (EIM) are common in patients with IBD, and occur in 6-47% of patients with CD or UC. EIM can involve organs other than the gastrointestinal tract such as skin, eyes, joints, biliary tract and kidneis. Renal and urinary involvement particularly occurs in 4-23% of patients with IBD. Among the renal complications of IBD, seconfary amyloidosis (AA-type, AAA) is a rare but serious complication. renal amyloidosis has been proven to be the most common lethal manifestation of IBD-associated amyloidosis, since renal involvement rapidly leads to end-stage renal failure. A few studies suggest that AAA is more prevalent in CD than in UC, mainly occurring in male patients with an extensive long-lasting and penetrating ddisease pattern. The therapeutic approaches of IBD-associated AAA are based both on control of the chronic inflammatory process that causes the production and storage of serum amyloid A (SAA), which is a precursor of the amyloid, as well as on destabilizing amyloid fibrils so that they can no longer maintain their pleated sheet configuration; however, in patients with end-stage renal disease, the only therapeutic options still available are hemodyalisis and renal transplantation. Whether effective treatment exists for AAA remain controversial.
Lingua originaleEnglish
pagine (da-a)5-13
Numero di pagine9
RivistaDefault journal
Volume19
Stato di pubblicazionePublished - 2017

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amyloidosis
inflammatory bowel disease
Amyloidosis
Inflammatory Bowel Diseases
Crohn disease
colitis
amyloid
Ulcerative Colitis
kidneys
Crohn Disease
Kidney
Amyloid
Chronic Kidney Failure
gastrointestinal system
Gastrointestinal Tract
biliary tract
Serum Amyloid A Protein
kidney transplant
therapeutics
Biliary Tract

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cita questo

Carini, F., Tomasello, G., Cappello, F., Raimondo, D., Pompei, G., Rizzo, A. G., ... Cappello, F. (2017). AMYLOIDOSIS AND INFLAMMATORY BOWEL DISEASE: FACT OR MITH? Default journal, 19, 5-13.

AMYLOIDOSIS AND INFLAMMATORY BOWEL DISEASE: FACT OR MITH? / Carini, Francesco; Tomasello, Giovanni; Cappello, Francesco; Raimondo, Dario; Pompei, Giancarlo; Rizzo, Aroldo Gabriele; Sinagra, Emanuele; Amvrosiadis, Georgios; Morreale, Gaetano Cristian; Canale, Carmelinda; Tomasello, Giovanni; Cappello, Francesco.

In: Default journal, Vol. 19, 2017, pag. 5-13.

Risultato della ricerca: Article

Carini, F, Tomasello, G, Cappello, F, Raimondo, D, Pompei, G, Rizzo, AG, Sinagra, E, Amvrosiadis, G, Morreale, GC, Canale, C, Tomasello, G & Cappello, F 2017, 'AMYLOIDOSIS AND INFLAMMATORY BOWEL DISEASE: FACT OR MITH?', Default journal, vol. 19, pagg. 5-13.
Carini, Francesco ; Tomasello, Giovanni ; Cappello, Francesco ; Raimondo, Dario ; Pompei, Giancarlo ; Rizzo, Aroldo Gabriele ; Sinagra, Emanuele ; Amvrosiadis, Georgios ; Morreale, Gaetano Cristian ; Canale, Carmelinda ; Tomasello, Giovanni ; Cappello, Francesco. / AMYLOIDOSIS AND INFLAMMATORY BOWEL DISEASE: FACT OR MITH?. In: Default journal. 2017 ; Vol. 19. pagg. 5-13.
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title = "AMYLOIDOSIS AND INFLAMMATORY BOWEL DISEASE: FACT OR MITH?",
abstract = "Inflammatory Bowel Disease (IBD), which includes both Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic idiopathic inflammatory disorder affecting the gastrointestinal tract. Extraintestinal manifestations (EIM) are common in patients with IBD, and occur in 6-47{\%} of patients with CD or UC. EIM can involve organs other than the gastrointestinal tract such as skin, eyes, joints, biliary tract and kidneis. Renal and urinary involvement particularly occurs in 4-23{\%} of patients with IBD. Among the renal complications of IBD, seconfary amyloidosis (AA-type, AAA) is a rare but serious complication. renal amyloidosis has been proven to be the most common lethal manifestation of IBD-associated amyloidosis, since renal involvement rapidly leads to end-stage renal failure. A few studies suggest that AAA is more prevalent in CD than in UC, mainly occurring in male patients with an extensive long-lasting and penetrating ddisease pattern. The therapeutic approaches of IBD-associated AAA are based both on control of the chronic inflammatory process that causes the production and storage of serum amyloid A (SAA), which is a precursor of the amyloid, as well as on destabilizing amyloid fibrils so that they can no longer maintain their pleated sheet configuration; however, in patients with end-stage renal disease, the only therapeutic options still available are hemodyalisis and renal transplantation. Whether effective treatment exists for AAA remain controversial.",
author = "Francesco Carini and Giovanni Tomasello and Francesco Cappello and Dario Raimondo and Giancarlo Pompei and Rizzo, {Aroldo Gabriele} and Emanuele Sinagra and Georgios Amvrosiadis and Morreale, {Gaetano Cristian} and Carmelinda Canale and Giovanni Tomasello and Francesco Cappello",
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AU - Carini, Francesco

AU - Tomasello, Giovanni

AU - Cappello, Francesco

AU - Raimondo, Dario

AU - Pompei, Giancarlo

AU - Rizzo, Aroldo Gabriele

AU - Sinagra, Emanuele

AU - Amvrosiadis, Georgios

AU - Morreale, Gaetano Cristian

AU - Canale, Carmelinda

AU - Tomasello, Giovanni

AU - Cappello, Francesco

PY - 2017

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N2 - Inflammatory Bowel Disease (IBD), which includes both Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic idiopathic inflammatory disorder affecting the gastrointestinal tract. Extraintestinal manifestations (EIM) are common in patients with IBD, and occur in 6-47% of patients with CD or UC. EIM can involve organs other than the gastrointestinal tract such as skin, eyes, joints, biliary tract and kidneis. Renal and urinary involvement particularly occurs in 4-23% of patients with IBD. Among the renal complications of IBD, seconfary amyloidosis (AA-type, AAA) is a rare but serious complication. renal amyloidosis has been proven to be the most common lethal manifestation of IBD-associated amyloidosis, since renal involvement rapidly leads to end-stage renal failure. A few studies suggest that AAA is more prevalent in CD than in UC, mainly occurring in male patients with an extensive long-lasting and penetrating ddisease pattern. The therapeutic approaches of IBD-associated AAA are based both on control of the chronic inflammatory process that causes the production and storage of serum amyloid A (SAA), which is a precursor of the amyloid, as well as on destabilizing amyloid fibrils so that they can no longer maintain their pleated sheet configuration; however, in patients with end-stage renal disease, the only therapeutic options still available are hemodyalisis and renal transplantation. Whether effective treatment exists for AAA remain controversial.

AB - Inflammatory Bowel Disease (IBD), which includes both Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic idiopathic inflammatory disorder affecting the gastrointestinal tract. Extraintestinal manifestations (EIM) are common in patients with IBD, and occur in 6-47% of patients with CD or UC. EIM can involve organs other than the gastrointestinal tract such as skin, eyes, joints, biliary tract and kidneis. Renal and urinary involvement particularly occurs in 4-23% of patients with IBD. Among the renal complications of IBD, seconfary amyloidosis (AA-type, AAA) is a rare but serious complication. renal amyloidosis has been proven to be the most common lethal manifestation of IBD-associated amyloidosis, since renal involvement rapidly leads to end-stage renal failure. A few studies suggest that AAA is more prevalent in CD than in UC, mainly occurring in male patients with an extensive long-lasting and penetrating ddisease pattern. The therapeutic approaches of IBD-associated AAA are based both on control of the chronic inflammatory process that causes the production and storage of serum amyloid A (SAA), which is a precursor of the amyloid, as well as on destabilizing amyloid fibrils so that they can no longer maintain their pleated sheet configuration; however, in patients with end-stage renal disease, the only therapeutic options still available are hemodyalisis and renal transplantation. Whether effective treatment exists for AAA remain controversial.

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