Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway.

Maria Antonietta Di Bella, Riccardo Alessandro, Simona Taverna, Marzia Pucci, Pablo Reclusa Asiain, Christian Rolfo, Riccardo Alessandro, Mariacarmela Santarpia, Ignacio Gil-Bazo, Simona Taverna, Pablo Reclusa

Risultato della ricerca: Article

28 Citazioni (Scopus)

Abstract

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone- recently found as a signaling molecule in exosomes derived from cancer cell lines. Exosomes have a key role in the cell-cell communication and they were recently indicated as important actors in
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine14
RivistaScientific Reports
Stato di pubblicazionePublished - 2017

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Exosomes
Osteoclasts
Non-Small Cell Lung Carcinoma
Bone and Bones
Cell Communication
Neoplasms
Neoplasm Metastasis
Cell Line
Amphiregulin

All Science Journal Classification (ASJC) codes

  • General

Cita questo

Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway. / Di Bella, Maria Antonietta; Alessandro, Riccardo; Taverna, Simona; Pucci, Marzia; Reclusa Asiain, Pablo; Rolfo, Christian; Alessandro, Riccardo; Santarpia, Mariacarmela; Gil-Bazo, Ignacio; Taverna, Simona; Reclusa, Pablo.

In: Scientific Reports, 2017, pag. -.

Risultato della ricerca: Article

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AU - Di Bella, Maria Antonietta

AU - Alessandro, Riccardo

AU - Taverna, Simona

AU - Pucci, Marzia

AU - Reclusa Asiain, Pablo

AU - Rolfo, Christian

AU - Alessandro, Riccardo

AU - Santarpia, Mariacarmela

AU - Gil-Bazo, Ignacio

AU - Taverna, Simona

AU - Reclusa, Pablo

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AB - Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone- recently found as a signaling molecule in exosomes derived from cancer cell lines. Exosomes have a key role in the cell-cell communication and they were recently indicated as important actors in

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M3 - Article

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JO - Scientific Reports

JF - Scientific Reports

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