Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway.

Maria Antonietta Di Bella, Riccardo Alessandro, Simona Taverna, Marzia Pucci, Pablo Reclusa Asiain, Christian Rolfo, Riccardo Alessandro, Mariacarmela Santarpia, Ignacio Gil-Bazo, Simona Taverna, Pablo Reclusa

Risultato della ricerca: Articlepeer review

41 Citazioni (Scopus)

Abstract

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone- recently found as a signaling molecule in exosomes derived from cancer cell lines. Exosomes have a key role in the cell-cell communication and they were recently indicated as important actors in
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine14
RivistaScientific Reports
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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