Amperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase

Viviana Figa', Yana Aleeva, Bruno Giuseppe Pignataro, Michelangelo Scopelliti, Gianluca Cannata, Graziella Scandurra, Vincenzo Vinciguerra, Gino Giusi, Michelangelo Scopelliti, Luigi G. Occhipinti, Carmine Ciofi, Giovanni Aldo Maira

Risultato della ricerca: Article

7 Citazioni (Scopus)

Abstract

Focusing on the interplay between interface chemistry, electrochemistry, and integrated electronics, we show a novel low-cost and flexible biosensing platform for continuous glucose monitoring. The amperometric biosensing system features a planar three-electrode structure on a plastic substrate, and a wireless NFC-powered electronic system performing sensor analog front-end (AFE), A/D conversion, digital control, and display tasks. The working electrode is made of electropolymerized poly(3,4-ethylenedioxythiophene) (PEDOT) film onto an Au/PET electrode followed by immobilization of cross-linked glucose oxidase by glutaraldehyde. The advantages offered by such a device, including low-cost materials and instrumentation as well as the good sensitivity of 9.24 μA/(mM · cm2) are promising tools for point-of-care monitoring. It is demonstrated that the devices are good candidates for the development of advanced sensing approaches based on the investigation of the noise produced during operation (Fluctuation Enhanced Sensing).
Lingua originaleEnglish
pagine (da-a)4869-4878
Numero di pagine10
RivistaDefault journal
Volume18
Stato di pubblicazionePublished - 2018

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Glucose oxidase
oxidase
bioinstrumentation
Biosensors
glucose
Glucose
Electronic equipment
Electrodes
electrodes
Monitoring
electronics
Electrochemistry
electrochemistry
immobilization
Costs
plastics
platforms
Display devices
chemistry
analogs

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Electrical and Electronic Engineering

Cita questo

Amperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase. / Figa', Viviana; Aleeva, Yana; Pignataro, Bruno Giuseppe; Scopelliti, Michelangelo; Cannata, Gianluca; Scandurra, Graziella; Vinciguerra, Vincenzo; Giusi, Gino; Scopelliti, Michelangelo; Occhipinti, Luigi G.; Ciofi, Carmine; Maira, Giovanni Aldo.

In: Default journal, Vol. 18, 2018, pag. 4869-4878.

Risultato della ricerca: Article

Figa', V, Aleeva, Y, Pignataro, BG, Scopelliti, M, Cannata, G, Scandurra, G, Vinciguerra, V, Giusi, G, Scopelliti, M, Occhipinti, LG, Ciofi, C & Maira, GA 2018, 'Amperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase', Default journal, vol. 18, pagg. 4869-4878.
Figa', Viviana ; Aleeva, Yana ; Pignataro, Bruno Giuseppe ; Scopelliti, Michelangelo ; Cannata, Gianluca ; Scandurra, Graziella ; Vinciguerra, Vincenzo ; Giusi, Gino ; Scopelliti, Michelangelo ; Occhipinti, Luigi G. ; Ciofi, Carmine ; Maira, Giovanni Aldo. / Amperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase. In: Default journal. 2018 ; Vol. 18. pagg. 4869-4878.
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AU - Aleeva, Yana

AU - Pignataro, Bruno Giuseppe

AU - Scopelliti, Michelangelo

AU - Cannata, Gianluca

AU - Scandurra, Graziella

AU - Vinciguerra, Vincenzo

AU - Giusi, Gino

AU - Scopelliti, Michelangelo

AU - Occhipinti, Luigi G.

AU - Ciofi, Carmine

AU - Maira, Giovanni Aldo

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AB - Focusing on the interplay between interface chemistry, electrochemistry, and integrated electronics, we show a novel low-cost and flexible biosensing platform for continuous glucose monitoring. The amperometric biosensing system features a planar three-electrode structure on a plastic substrate, and a wireless NFC-powered electronic system performing sensor analog front-end (AFE), A/D conversion, digital control, and display tasks. The working electrode is made of electropolymerized poly(3,4-ethylenedioxythiophene) (PEDOT) film onto an Au/PET electrode followed by immobilization of cross-linked glucose oxidase by glutaraldehyde. The advantages offered by such a device, including low-cost materials and instrumentation as well as the good sensitivity of 9.24 μA/(mM · cm2) are promising tools for point-of-care monitoring. It is demonstrated that the devices are good candidates for the development of advanced sensing approaches based on the investigation of the noise produced during operation (Fluctuation Enhanced Sensing).

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