Nowadays the therapeutic strategies to manage Parkinson’s Disease are merely symptomatic and consist of administering L-DOPA and/or dopamine receptor agonists. Among these, Ropinirole (ROP) is a widely orally-administered molecule, although it is extensively susceptible to hepatic metabolism. Since literature reports the buccal mucosa as a potentially useful route to ROP administration, the development of novel, eﬀective, and comfortable oromucosal formulations should prove desirable in order to both enhance the therapeutic eﬃcacy of the drug and allow a personalized therapeutic strategy able to meet the patient’s needs. The results of the proposed ROP ﬁlm as a new dosage form show that it is ﬂexible; uniform; and characterized by suitable surface pH; good mucoadhesiveness; low swelling degree; and fast, complete drug release. Moreover, after ex vivo evaluation on a ﬁlm having an area of 0.282 cm2 and dose of 2.29 mg, the results of drug ﬂux through the buccal mucosa are closely comparable to the amount of ROP that reaches the bloodstream at the steady-state condition after ROP-PR 4 mg oral administration, calculated according to the literature (0.237 mg/cm2·h−1 vs. 0.243 mg/h, respectively). Moreover, drug ﬂux and ROP dose could be accurately modulated time-by-time depending on the patient’s need, by varying the administered disk area. In addition, the proposed ROP ﬁlm displays no lag time, producing an immediate drug input in the bloodstream, which could result in a prompt therapeutic response. These ﬁndings make ROP ﬁlm a potentially comfortable and patient-friendly formulation, and a promising candidate for further clinical trials.
|Numero di pagine||17|
|Rivista||Journal of Personalized Medicine|
|Stato di pubblicazione||Published - 2020|
All Science Journal Classification (ASJC) codes