Aminobisphosphonate-activated gammadelta T cells in immunotherapy of cancer:doubts no more.

Risultato della ricerca: Article

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Abstract

BACKGROUND: Activated V gamma 9 V delta 2 T cells are able to kill mosttumour cells because of recognition by T cell receptor and natural killerreceptors.OBJECTIVE: We discuss the possibility that the intentional activation ofgammadelta T cells in vivo by aminobisphosphonates may represent a promisingtarget for the design of novel and highly innovative immunotherapy in cancerpatients.METHODS: The antitumoral effects of gammadelta T cells both in vitro and invivo have been demonstrated suggesting a new therapeutic approach fortranslation into the clinical setting.RESULTS/CONCLUSION: V gamma 9 V delta 2 T lymphocytes represent aparticularly interesting target for immunotherapeutic protocols based on N-aminobisphosphonate administration and several Phase I-II trials are ongoinginvestigating the activity of zoledronic acid plus IL-2 in solid tumours.
Lingua originaleEnglish
pagine (da-a)875-883
Numero di pagine9
RivistaExpert Opinion on Biological Therapy
Volume8(7)
Stato di pubblicazionePublished - 2008

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T-cells
Immunotherapy
T-Lymphocytes
zoledronic acid
Neoplasms
T-Cell Antigen Receptor
Interleukin-2
Tumors
Chemical activation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cita questo

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title = "Aminobisphosphonate-activated gammadelta T cells in immunotherapy of cancer:doubts no more.",
abstract = "BACKGROUND: Activated V gamma 9 V delta 2 T cells are able to kill mosttumour cells because of recognition by T cell receptor and natural killerreceptors.OBJECTIVE: We discuss the possibility that the intentional activation ofgammadelta T cells in vivo by aminobisphosphonates may represent a promisingtarget for the design of novel and highly innovative immunotherapy in cancerpatients.METHODS: The antitumoral effects of gammadelta T cells both in vitro and invivo have been demonstrated suggesting a new therapeutic approach fortranslation into the clinical setting.RESULTS/CONCLUSION: V gamma 9 V delta 2 T lymphocytes represent aparticularly interesting target for immunotherapeutic protocols based on N-aminobisphosphonate administration and several Phase I-II trials are ongoinginvestigating the activity of zoledronic acid plus IL-2 in solid tumours.",
keywords = "Aminobisphosphonate, Gamma delta T cells, cancer",
author = "Serena Meraviglia and Alfredo Salerno and Gabriella Misiano and {La Mendola}, Carmela and Caccamo, {Nadia Rosalia} and Francesco Dieli and Cesira Bonanno and Daniele Santini and Francesco Scarpa",
year = "2008",
language = "English",
volume = "8(7)",
pages = "875--883",
journal = "Expert Opinion on Biological Therapy",
issn = "1471-2598",
publisher = "Informa Healthcare",

}

TY - JOUR

T1 - Aminobisphosphonate-activated gammadelta T cells in immunotherapy of cancer:doubts no more.

AU - Meraviglia, Serena

AU - Salerno, Alfredo

AU - Misiano, Gabriella

AU - La Mendola, Carmela

AU - Caccamo, Nadia Rosalia

AU - Dieli, Francesco

AU - Bonanno, Cesira

AU - Santini, Daniele

AU - Scarpa, Francesco

PY - 2008

Y1 - 2008

N2 - BACKGROUND: Activated V gamma 9 V delta 2 T cells are able to kill mosttumour cells because of recognition by T cell receptor and natural killerreceptors.OBJECTIVE: We discuss the possibility that the intentional activation ofgammadelta T cells in vivo by aminobisphosphonates may represent a promisingtarget for the design of novel and highly innovative immunotherapy in cancerpatients.METHODS: The antitumoral effects of gammadelta T cells both in vitro and invivo have been demonstrated suggesting a new therapeutic approach fortranslation into the clinical setting.RESULTS/CONCLUSION: V gamma 9 V delta 2 T lymphocytes represent aparticularly interesting target for immunotherapeutic protocols based on N-aminobisphosphonate administration and several Phase I-II trials are ongoinginvestigating the activity of zoledronic acid plus IL-2 in solid tumours.

AB - BACKGROUND: Activated V gamma 9 V delta 2 T cells are able to kill mosttumour cells because of recognition by T cell receptor and natural killerreceptors.OBJECTIVE: We discuss the possibility that the intentional activation ofgammadelta T cells in vivo by aminobisphosphonates may represent a promisingtarget for the design of novel and highly innovative immunotherapy in cancerpatients.METHODS: The antitumoral effects of gammadelta T cells both in vitro and invivo have been demonstrated suggesting a new therapeutic approach fortranslation into the clinical setting.RESULTS/CONCLUSION: V gamma 9 V delta 2 T lymphocytes represent aparticularly interesting target for immunotherapeutic protocols based on N-aminobisphosphonate administration and several Phase I-II trials are ongoinginvestigating the activity of zoledronic acid plus IL-2 in solid tumours.

KW - Aminobisphosphonate

KW - Gamma delta T cells

KW - cancer

UR - http://hdl.handle.net/10447/37793

M3 - Article

VL - 8(7)

SP - 875

EP - 883

JO - Expert Opinion on Biological Therapy

JF - Expert Opinion on Biological Therapy

SN - 1471-2598

ER -