TY - JOUR
T1 - Amelanotic conjunctival melanoma
AU - Aragona, Federico
AU - Lodato, Gaetano
AU - Bongiorno, Maria Rita
AU - Arico', Mario
PY - 2006
Y1 - 2006
N2 - Conjunctival melanoma is a rare condition of the eye pigment predominantly affecting white adults. We describe a 32-year-old white man with an amelanotic malignant melanoma of the conjunctiva that is not associated with primary acquired melanosis (PAM) or melanocytic nevus. The patient presented with a 2-year history of nonpigmented vascularized nodules of the right eye. Results of hematoxylin and eosin (H and E) staining of the lesion showed an invasive nodule with vertical spreading, invasion of the substantia propria corneae, and ulceration. S100 protein was expressed in the cells of the invasive nodule. HMB45 protein was highly positive in the melanoma cells. The de novo amelanotic malignant melanoma of the conjunctiva we describe is an extremely uncommon tumor mainly affecting white adults.
AB - Conjunctival melanoma is a rare condition of the eye pigment predominantly affecting white adults. We describe a 32-year-old white man with an amelanotic malignant melanoma of the conjunctiva that is not associated with primary acquired melanosis (PAM) or melanocytic nevus. The patient presented with a 2-year history of nonpigmented vascularized nodules of the right eye. Results of hematoxylin and eosin (H and E) staining of the lesion showed an invasive nodule with vertical spreading, invasion of the substantia propria corneae, and ulceration. S100 protein was expressed in the cells of the invasive nodule. HMB45 protein was highly positive in the melanoma cells. The de novo amelanotic malignant melanoma of the conjunctiva we describe is an extremely uncommon tumor mainly affecting white adults.
KW - Conjunctival melanoma
KW - amelanotic malignant melanoma
KW - primary acquired melanosis (PAM).
KW - Conjunctival melanoma
KW - amelanotic malignant melanoma
KW - primary acquired melanosis (PAM).
UR - http://hdl.handle.net/10447/19045
M3 - Article
VL - 77(6)
SP - 377
EP - 381
JO - Cutis
JF - Cutis
SN - 0011-4162
ER -