Alzheimer patients engage an alternative cortical network during a memory task.

Lisa Cipolotti, Richard S. J. Frackowiak, Francois Chollet, Michèle Puel, Linda Clare, Jean Francois Demonet, Richard Henson, Martin Rossor, Angus Kennedy, Jérémie Pariente, Susanna Cole, Lisa Cipoloti

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133 Citazioni (Scopus)


We conducted an event-related functional magnetic resonance imaging experiment to better understand the potentiallycompensatory alternative brain networks activated by a clinically relevant face-name association task in Alzheimer’sdisease (AD) patients and matched control subjects. We recruited 17 healthy subjects and 12 AD patients at an earlystage of the disease. They underwent functional magnetic resonance imaging scanning in four sessions. Each of thesessions combined a “study” phase and a “test” phase. Face/name pairs were presented in each study phase, and subjectswere asked to associate faces with names. In the test phase, a recognition task, faces seen in the study phase werepresented each with four different names. The task required selection of appropriate previously associated names fromthe study phase. Responses were recorded for post hoc classification into those successfully or unsuccessfully encoded.There were significant differences between the groups in accuracy and reaction time. Comparison of correctly versusincorrectly encoded and recognized pairs in the two groups indicated bilateral hippocampal hypoactivation both whenencoding and recognizing in the AD group. Moreover, patients showed bilateral hyperactivation of parts of the parietaland frontal lobes. We discuss whether hyperactivation of a frontoparietal network reflects compensatory strategies forfailing associative memory in AD patients.
Lingua originaleEnglish
pagine (da-a)870-879
Numero di pagine10
RivistaAnnals of Neurology
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2728???


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