Altered processing of sensory stimuli in patients with migraine.

Filippo Brighina, Gianluca Coppola, Daniele Marinazzo, Sebastiano Stramaglia, Francesco Pierelli, Anna Ambrosini, Marina De Tommaso, Armando Perrotta, Massimiliano Valeriani, Giorgio Sandrini, Jean Schoenen

Risultato della ricerca: Articlepeer review

146 Citazioni (Scopus)


Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. To test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.
Lingua originaleEnglish
Numero di pagine12
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2728???
  • ???subjectarea.asjc.2800.2804???


Entra nei temi di ricerca di 'Altered processing of sensory stimuli in patients with migraine.'. Insieme formano una fingerprint unica.

Cita questo