Alfa-lipoic acid and superoxide dismutase in the management of chronic neck pain: a prospective randomized study

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Abstract

Background. Oxidative stress plays a role in several neuropathies, including chronic neckpain (CNP), and oral antioxidants may improve pain control and enhance the efficacy of physiotherapy (“multimodal therapy”).Aim. To compare 4-lipoic acid (ALA) and superoxide dismutase (SOD) in association tophysiotherapy vs. physiotherapy alone in CNP patients.Design: Prospective, randomized, open study.Setting: Rehabilitation Unit, Department of Surgical and Oncological Sciences (Palermo,Italy).Population: Outpatients.Methods: Patients randomly received either ALA 600 mg and SOD 140 I.U. daily inaddition to physiotherapy (Group 1; n = 51) or physiotherapy alone (Group 2; n = 45), for60 days. Pain was assessed by visual analogue scale (VAS) and modified Neck PainQuestionnaire (mNPQ). Treatment compliance and safety were evaluated.Results: Both groups experienced a significant reduction in VAS and mNPQ scores afterone month; however, while no further improvement was observed in group 2 at 60 days,group 1 showed a further VAS reduction (p < 0.001 vs. group 2). In addition, more patients in group 1 than in group 2 reported their neck pain to be improved at mNPQ at 60 days (p <0.01), and showed a higher compliance to medical prescriptions (p = 0.048). No drug reaction was observed.Conclusion: ALA/SOD association to physiotherapy may be an useful approach to CNP, being antioxidants active on nerve inflammation and disease progression.Clinical Rehabilitation interesting goals (better pain control and physical well-being) can be reached by multimodaltherapy in CNP patients.
Lingua originaleEnglish
pagine (da-a)1-7
Numero di pagine7
RivistaDefault journal
Volume14
Stato di pubblicazionePublished - 2014

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Thioctic Acid
Neck Pain
Chronic Pain
Superoxide Dismutase
Visual Analog Scale
Prospective Studies
Neck
Pain
Rehabilitation
Antioxidants
Italy
Prescriptions
Disease Progression
Oxidative Stress
Outpatients
Inflammation
Safety
Therapeutics
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology

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title = "Alfa-lipoic acid and superoxide dismutase in the management of chronic neck pain: a prospective randomized study",
abstract = "Background. Oxidative stress plays a role in several neuropathies, including chronic neckpain (CNP), and oral antioxidants may improve pain control and enhance the efficacy of physiotherapy (“multimodal therapy”).Aim. To compare 4-lipoic acid (ALA) and superoxide dismutase (SOD) in association tophysiotherapy vs. physiotherapy alone in CNP patients.Design: Prospective, randomized, open study.Setting: Rehabilitation Unit, Department of Surgical and Oncological Sciences (Palermo,Italy).Population: Outpatients.Methods: Patients randomly received either ALA 600 mg and SOD 140 I.U. daily inaddition to physiotherapy (Group 1; n = 51) or physiotherapy alone (Group 2; n = 45), for60 days. Pain was assessed by visual analogue scale (VAS) and modified Neck PainQuestionnaire (mNPQ). Treatment compliance and safety were evaluated.Results: Both groups experienced a significant reduction in VAS and mNPQ scores afterone month; however, while no further improvement was observed in group 2 at 60 days,group 1 showed a further VAS reduction (p < 0.001 vs. group 2). In addition, more patients in group 1 than in group 2 reported their neck pain to be improved at mNPQ at 60 days (p <0.01), and showed a higher compliance to medical prescriptions (p = 0.048). No drug reaction was observed.Conclusion: ALA/SOD association to physiotherapy may be an useful approach to CNP, being antioxidants active on nerve inflammation and disease progression.Clinical Rehabilitation interesting goals (better pain control and physical well-being) can be reached by multimodaltherapy in CNP patients.",
author = "Antonino Sanfilippo and Pietro Cataldo and Giuseppa Barbera and {Letizia Mauro}, Giulia",
year = "2014",
language = "English",
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T1 - Alfa-lipoic acid and superoxide dismutase in the management of chronic neck pain: a prospective randomized study

AU - Sanfilippo, Antonino

AU - Cataldo, Pietro

AU - Barbera, Giuseppa

AU - Letizia Mauro, Giulia

PY - 2014

Y1 - 2014

N2 - Background. Oxidative stress plays a role in several neuropathies, including chronic neckpain (CNP), and oral antioxidants may improve pain control and enhance the efficacy of physiotherapy (“multimodal therapy”).Aim. To compare 4-lipoic acid (ALA) and superoxide dismutase (SOD) in association tophysiotherapy vs. physiotherapy alone in CNP patients.Design: Prospective, randomized, open study.Setting: Rehabilitation Unit, Department of Surgical and Oncological Sciences (Palermo,Italy).Population: Outpatients.Methods: Patients randomly received either ALA 600 mg and SOD 140 I.U. daily inaddition to physiotherapy (Group 1; n = 51) or physiotherapy alone (Group 2; n = 45), for60 days. Pain was assessed by visual analogue scale (VAS) and modified Neck PainQuestionnaire (mNPQ). Treatment compliance and safety were evaluated.Results: Both groups experienced a significant reduction in VAS and mNPQ scores afterone month; however, while no further improvement was observed in group 2 at 60 days,group 1 showed a further VAS reduction (p < 0.001 vs. group 2). In addition, more patients in group 1 than in group 2 reported their neck pain to be improved at mNPQ at 60 days (p <0.01), and showed a higher compliance to medical prescriptions (p = 0.048). No drug reaction was observed.Conclusion: ALA/SOD association to physiotherapy may be an useful approach to CNP, being antioxidants active on nerve inflammation and disease progression.Clinical Rehabilitation interesting goals (better pain control and physical well-being) can be reached by multimodaltherapy in CNP patients.

AB - Background. Oxidative stress plays a role in several neuropathies, including chronic neckpain (CNP), and oral antioxidants may improve pain control and enhance the efficacy of physiotherapy (“multimodal therapy”).Aim. To compare 4-lipoic acid (ALA) and superoxide dismutase (SOD) in association tophysiotherapy vs. physiotherapy alone in CNP patients.Design: Prospective, randomized, open study.Setting: Rehabilitation Unit, Department of Surgical and Oncological Sciences (Palermo,Italy).Population: Outpatients.Methods: Patients randomly received either ALA 600 mg and SOD 140 I.U. daily inaddition to physiotherapy (Group 1; n = 51) or physiotherapy alone (Group 2; n = 45), for60 days. Pain was assessed by visual analogue scale (VAS) and modified Neck PainQuestionnaire (mNPQ). Treatment compliance and safety were evaluated.Results: Both groups experienced a significant reduction in VAS and mNPQ scores afterone month; however, while no further improvement was observed in group 2 at 60 days,group 1 showed a further VAS reduction (p < 0.001 vs. group 2). In addition, more patients in group 1 than in group 2 reported their neck pain to be improved at mNPQ at 60 days (p <0.01), and showed a higher compliance to medical prescriptions (p = 0.048). No drug reaction was observed.Conclusion: ALA/SOD association to physiotherapy may be an useful approach to CNP, being antioxidants active on nerve inflammation and disease progression.Clinical Rehabilitation interesting goals (better pain control and physical well-being) can be reached by multimodaltherapy in CNP patients.

UR - http://hdl.handle.net/10447/96574

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EP - 7

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JF - Default journal

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