Alfa-lipoic acid and superoxide dismutase in the management of chronic neck pain: a prospective randomized study

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Background. Oxidative stress plays a role in several neuropathies, including chronic neckpain (CNP), and oral antioxidants may improve pain control and enhance the efficacy of physiotherapy (“multimodal therapy”).Aim. To compare 4-lipoic acid (ALA) and superoxide dismutase (SOD) in association tophysiotherapy vs. physiotherapy alone in CNP patients.Design: Prospective, randomized, open study.Setting: Rehabilitation Unit, Department of Surgical and Oncological Sciences (Palermo,Italy).Population: Outpatients.Methods: Patients randomly received either ALA 600 mg and SOD 140 I.U. daily inaddition to physiotherapy (Group 1; n = 51) or physiotherapy alone (Group 2; n = 45), for60 days. Pain was assessed by visual analogue scale (VAS) and modified Neck PainQuestionnaire (mNPQ). Treatment compliance and safety were evaluated.Results: Both groups experienced a significant reduction in VAS and mNPQ scores afterone month; however, while no further improvement was observed in group 2 at 60 days,group 1 showed a further VAS reduction (p < 0.001 vs. group 2). In addition, more patients in group 1 than in group 2 reported their neck pain to be improved at mNPQ at 60 days (p <0.01), and showed a higher compliance to medical prescriptions (p = 0.048). No drug reaction was observed.Conclusion: ALA/SOD association to physiotherapy may be an useful approach to CNP, being antioxidants active on nerve inflammation and disease progression.Clinical Rehabilitation interesting goals (better pain control and physical well-being) can be reached by multimodaltherapy in CNP patients.
Lingua originaleEnglish
pagine (da-a)1-7
Numero di pagine7
RivistaDRUGS IN R&amp;D
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

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