Albumin replacement therapy in immunocompromised patients with sepsis - Secondary analysis of the ALBIOS trial

Antonino Giarratano, Andrea Cortegiani, Stefano Romagnoli, Giacomo Grasselli, Jennifer Meessen, Fabrizio Turvani, Roberto Latini, Chiara Maria Bonenti, Roberto Latini, Giacomo Bellani, Pietro Caironi, Carlo Alberto Volta, Roberto Latini, Antonio Pesenti, Alessandra Moscarelli, Mariachiara Ippolito

Risultato della ricerca: Articlepeer review


Background: The best fluid replacement strategy and the role of albumin in immunocompromised patients with sepsis is unclear.Methods: We performed a secondary analysis of immunocompromised patients enrolled in the ALBIOS trial which randomized patients with severe sepsis or septic shock to receive either 20% albumin (target 30 g per liter or more) and crystalloid or crystalloid alone during ICU stay.Results: Of 1818 patients originally enrolled, 304 (16.4%) were immunocompromised. One-hundred-thirty-nine (45.7%) patients were randomized in the albumin while 165 (54.2%) in the crystalloid group. At 90 days, 69 (49.6%) in the albumin group and 89 (53.9%) in the crystalloids group died (hazard ratio - HR - 0.94; 95% CI 0.69-1.29). No differences were observed with regards to 28-day mortality, SOFA score (and sub-scores), length of stay in the ICU and in the hospital, proportion of patients who had developed acute kidney injury or received renal replacement therapy, duration of mechanical ventilation. Albumin was not independently associated with a higher or lower 90-day mortality (HR 0.979, 95% CI 0.709-1.352) as compared to crystalloid.Conclusion: Albumin replacement during the ICU stay, as compared with crystalloids alone, did not affect clinical outcomes in a cohort of immunocompromised patients with sepsis.
Lingua originaleEnglish
pagine (da-a)83-91
Numero di pagine9
RivistaJournal of Critical Care
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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