Airways hyperresponsiveness and the effects of lung inflation

Nicola Scichilone, Trigsevgeni Kapsali, George Pyrgos, Solbert Permutt, Alkis Togias, Christina Anderlind, Robert Brown

Risultato della ricerca: Article

32 Citazioni (Scopus)

Abstract

Lung inflation has a beneficial effect on the airways of healthy subjects. It acts as a bronchoprotector, that is to prevent bronchoconstriction, and as a bronchodilator, in that it reverses bronchial obstruction. The bronchoprotective effect of deep inspiration is more potent than the bronchodilatory one, and the two phenomena appear to advocate different mechanisms. Asthmatics and rhinitics with airways hyperresponsiveness show an impairment in bronchoprotection induced by deep breaths, whereas the bronchodilatory effect, although reduced, is still effective. The lack of the bronchoprotective effect of deep inspiration may contribute to the development of airways hyperresponsiveness. The mechanisms through which lung inflation exerts its beneficial role in healthy subjects, and the factors impairing such an effect in those with airways hyperresponsiveness, are currently under investigation.
Lingua originaleEnglish
pagine (da-a)262-6-
Numero di pagine5
RivistaInternational Archives of Allergy and Immunology
Volume124
Stato di pubblicazionePublished - 2001

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Economic Inflation
Healthy Volunteers
Lung
Bronchoconstriction
Bronchodilator Agents

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cita questo

Scichilone, N., Kapsali, T., Pyrgos, G., Permutt, S., Togias, A., Anderlind, C., & Brown, R. (2001). Airways hyperresponsiveness and the effects of lung inflation. International Archives of Allergy and Immunology, 124, 262-6-.

Airways hyperresponsiveness and the effects of lung inflation. / Scichilone, Nicola; Kapsali, Trigsevgeni; Pyrgos, George; Permutt, Solbert; Togias, Alkis; Anderlind, Christina; Brown, Robert.

In: International Archives of Allergy and Immunology, Vol. 124, 2001, pag. 262-6-.

Risultato della ricerca: Article

Scichilone, N, Kapsali, T, Pyrgos, G, Permutt, S, Togias, A, Anderlind, C & Brown, R 2001, 'Airways hyperresponsiveness and the effects of lung inflation', International Archives of Allergy and Immunology, vol. 124, pagg. 262-6-.
Scichilone N, Kapsali T, Pyrgos G, Permutt S, Togias A, Anderlind C e altri. Airways hyperresponsiveness and the effects of lung inflation. International Archives of Allergy and Immunology. 2001;124:262-6-.
Scichilone, Nicola ; Kapsali, Trigsevgeni ; Pyrgos, George ; Permutt, Solbert ; Togias, Alkis ; Anderlind, Christina ; Brown, Robert. / Airways hyperresponsiveness and the effects of lung inflation. In: International Archives of Allergy and Immunology. 2001 ; Vol. 124. pagg. 262-6-.
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AU - Togias, Alkis

AU - Anderlind, Christina

AU - Brown, Robert

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AB - Lung inflation has a beneficial effect on the airways of healthy subjects. It acts as a bronchoprotector, that is to prevent bronchoconstriction, and as a bronchodilator, in that it reverses bronchial obstruction. The bronchoprotective effect of deep inspiration is more potent than the bronchodilatory one, and the two phenomena appear to advocate different mechanisms. Asthmatics and rhinitics with airways hyperresponsiveness show an impairment in bronchoprotection induced by deep breaths, whereas the bronchodilatory effect, although reduced, is still effective. The lack of the bronchoprotective effect of deep inspiration may contribute to the development of airways hyperresponsiveness. The mechanisms through which lung inflation exerts its beneficial role in healthy subjects, and the factors impairing such an effect in those with airways hyperresponsiveness, are currently under investigation.

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