Airway inflammation in patients affected by obstructive sleep apnea syndrome

Maria Rosaria Bonsignore, Salerno, Roberti, Carpagnano, Maria Aliani, Guido, Antonio Spanevello, Vignola, Antonio Maurizio Vignola

Risultato della ricerca: Article

73 Citazioni (Scopus)

Abstract

Obstructive sleep apnea syndrome (OSAS) has been shown to be associated to upper airway inflammation. The object of the present study was to establish the presence of bronchial inflammation in OSAS subjects. In 16 subjects affected by OSAS, and in 14 healthy volunteers, airway inflammation was detected by the cellular analysis of the induced sputum. OSAS patients, as compared to control subjects, showed a higher percentage of neutrophils (66.7±18.9 vs. 25.8±15.6) (P<0.001) and a lower percentage of macrophages (29.4±18.4 vs. 70.8±15.3) (P<0.001). The percentage of eosinophils and lymphocytes were not significantly different in the two groups. OSAS subjects show bronchial inflammation characterized by a significant increase in neutrophils.
Lingua originaleEnglish
pagine (da-a)25-28
Numero di pagine4
RivistaRespiratory Medicine
Volume98
Stato di pubblicazionePublished - 2004

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Obstructive Sleep Apnea
Inflammation
Neutrophils
Sputum
Eosinophils
Healthy Volunteers
Macrophages
Lymphocytes

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cita questo

Bonsignore, M. R., Salerno, Roberti, Carpagnano, Aliani, M., Guido, ... Vignola, A. M. (2004). Airway inflammation in patients affected by obstructive sleep apnea syndrome. Respiratory Medicine, 98, 25-28.

Airway inflammation in patients affected by obstructive sleep apnea syndrome. / Bonsignore, Maria Rosaria; Salerno; Roberti; Carpagnano; Aliani, Maria; Guido; Spanevello, Antonio; Vignola; Vignola, Antonio Maurizio.

In: Respiratory Medicine, Vol. 98, 2004, pag. 25-28.

Risultato della ricerca: Article

Bonsignore, MR, Salerno, Roberti, Carpagnano, Aliani, M, Guido, Spanevello, A, Vignola & Vignola, AM 2004, 'Airway inflammation in patients affected by obstructive sleep apnea syndrome', Respiratory Medicine, vol. 98, pagg. 25-28.
Bonsignore MR, Salerno, Roberti, Carpagnano, Aliani M, Guido e altri. Airway inflammation in patients affected by obstructive sleep apnea syndrome. Respiratory Medicine. 2004;98:25-28.
Bonsignore, Maria Rosaria ; Salerno ; Roberti ; Carpagnano ; Aliani, Maria ; Guido ; Spanevello, Antonio ; Vignola ; Vignola, Antonio Maurizio. / Airway inflammation in patients affected by obstructive sleep apnea syndrome. In: Respiratory Medicine. 2004 ; Vol. 98. pagg. 25-28.
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AU - Bonsignore, Maria Rosaria

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AU - Roberti, null

AU - Carpagnano, null

AU - Aliani, Maria

AU - Guido, null

AU - Spanevello, Antonio

AU - Vignola, null

AU - Vignola, Antonio Maurizio

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N2 - Obstructive sleep apnea syndrome (OSAS) has been shown to be associated to upper airway inflammation. The object of the present study was to establish the presence of bronchial inflammation in OSAS subjects. In 16 subjects affected by OSAS, and in 14 healthy volunteers, airway inflammation was detected by the cellular analysis of the induced sputum. OSAS patients, as compared to control subjects, showed a higher percentage of neutrophils (66.7±18.9 vs. 25.8±15.6) (P<0.001) and a lower percentage of macrophages (29.4±18.4 vs. 70.8±15.3) (P<0.001). The percentage of eosinophils and lymphocytes were not significantly different in the two groups. OSAS subjects show bronchial inflammation characterized by a significant increase in neutrophils.

AB - Obstructive sleep apnea syndrome (OSAS) has been shown to be associated to upper airway inflammation. The object of the present study was to establish the presence of bronchial inflammation in OSAS subjects. In 16 subjects affected by OSAS, and in 14 healthy volunteers, airway inflammation was detected by the cellular analysis of the induced sputum. OSAS patients, as compared to control subjects, showed a higher percentage of neutrophils (66.7±18.9 vs. 25.8±15.6) (P<0.001) and a lower percentage of macrophages (29.4±18.4 vs. 70.8±15.3) (P<0.001). The percentage of eosinophils and lymphocytes were not significantly different in the two groups. OSAS subjects show bronchial inflammation characterized by a significant increase in neutrophils.

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