Aggressive Pharmacological Treatment for Reversing Malignant Bowel Obstruction

Antonio Marrazzo, Sebastiano Mercadante, Antonio Marrazzo, Patrizia Villari, Patrizia Ferrera

Risultato della ricerca: Article

68 Citazioni (Scopus)

Abstract

Early and intensive pharmacological treatment not only may reduce gastrointestinal symptoms but also reverse malignant bowel obstruction. Fifteen consecutive advanced cancer patients with inoperable bowel obstruction received a combination of drugs including metoclopramide, octreotide, dexamethasone and an initial bolus of amidotrizoato. Recovery of intestinal transit was reported within 1-5 days in fourteen patients, who continued this treatment without presenting symptoms of bowel obstruction until death. This case series establishes that the combination of propulsive and antisecretive agents can act synergistically to allow a fast recovery of bowel transit without inducing unpleasant colic. It suggests that the most important mechanism in these circumstances is functional and can be reversible, if an aggressive treatment is initiated early before fecal impaction and edema render bowel obstruction irreversible.
Lingua originaleEnglish
pagine (da-a)412-416
RivistaJournal of Pain and Symptom Management
Volume28 (4)
Stato di pubblicazionePublished - 2004

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Pharmacology
Fecal Impaction
Metoclopramide
Octreotide
Colic
Drug Combinations
Dexamethasone
Edema
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Nursing(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cita questo

Marrazzo, A., Mercadante, S., Marrazzo, A., Villari, P., & Ferrera, P. (2004). Aggressive Pharmacological Treatment for Reversing Malignant Bowel Obstruction. Journal of Pain and Symptom Management, 28 (4), 412-416.

Aggressive Pharmacological Treatment for Reversing Malignant Bowel Obstruction. / Marrazzo, Antonio; Mercadante, Sebastiano; Marrazzo, Antonio; Villari, Patrizia; Ferrera, Patrizia.

In: Journal of Pain and Symptom Management, Vol. 28 (4), 2004, pag. 412-416.

Risultato della ricerca: Article

Marrazzo, A, Mercadante, S, Marrazzo, A, Villari, P & Ferrera, P 2004, 'Aggressive Pharmacological Treatment for Reversing Malignant Bowel Obstruction', Journal of Pain and Symptom Management, vol. 28 (4), pagg. 412-416.
Marrazzo, Antonio ; Mercadante, Sebastiano ; Marrazzo, Antonio ; Villari, Patrizia ; Ferrera, Patrizia. / Aggressive Pharmacological Treatment for Reversing Malignant Bowel Obstruction. In: Journal of Pain and Symptom Management. 2004 ; Vol. 28 (4). pagg. 412-416.
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