AGE6. Skin Ageing: Focus on the Role of Inflammatory GeneticFactors in Cutaneous NeoplasiaC. M. Gambino1, F. Crapanzano1, G. Accardi1, A. Aiello1, C. Virruso1, G.Pistone1, M. R. Bongiorno1, D. Lio1, C. R. Balistreri1, G. Candore11University of Palermo, Palermo, ItalyBackground: Skin aging is a complex process that involves intrinsic andexogenous causes. Photo-oxidative damage caused by UV is the leadingcause of extrinsic aging of the skin, known as photo-ageing. UV damagescan be linked mostly to overproduction of ROS that induces a complexmolecular cascade able to accelerate physiological aging, determining atypical dermal/epidermal inflammation with an increased risk of gettingskin cancer. The skin response is strongly influenced by individual geneticbackground. Thus, polymorphisms in candidate inflammatory genes mightplay a role in photo-ageing and skin cancer.Methods: A total of 30 Sicilian subjects (12 females and 18 males; agerange, 65–90 years) were enrolled. From histo-pathological data, 12subjects showed skin cancer. Their blood samples have been used toobtain DNA samples and have been genotyped for TLR4 (+896 A/G;rs.4986790), TLR4 (+1196 C/T, rs.4986791), MMP2 (-1306 C/T,rs.243865) and MMP9 (-1562 C/T, rs.3918242) using a RFLP-PCR.Results: Allelic and genotypic frequencies of the SNPs analysed wereevaluated by gene count. No significant differences in frequencies ofthese SNPs among cases and controls were observed.Conclusions: Our results are preliminary, so it is certainly necessary toincrease the sample size of our study. In fact, the possible role of theseSNPs in skin-ageing related neoplasia might open new perspectives fortheir analysis and prevention. However, it is imperative to underline theconcept that functional effects of each SNP depend on the presence ofone or different environmental causes (UV radiation, smoking, etc.).
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2014


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