Age-Related Inflammation: the Contribution of Different Organs, Tissues andSystems. How to Face it for Therapeutic Approaches

Sonya Vasto, Giuseppina Candore, Giuseppina Colonna Romano, Calogero Caruso, Domenico Lio, Claudia Maria Rizzo, Domenico Nuzzo, Cevenini, Scurti, Palmas, Pini, Claudio Franceschi, Giovanni Duro, Miriam Capri

Risultato della ricerca: Article

114 Citazioni (Scopus)

Abstract

A typical feature of ageing is a chronic, low-grade inflammation characterized by a general increase in the production of proinflammatorycytokines and inflammatory markers (“inflamm-ageing”). This status may slowly damage one or several organs, especiallywhen unfavorable genetic polymorphisms and epigenetic alterations are concomitant, leading to an increased risk of frailty together withthe onset of age-related chronic diseases. The contribution of different tissues (adipose tissue, muscle), organs (brain, liver), immunesystem and ecosystems (gut microbiota) to age-related inflammation (“inflamm-ageing”) will be discussed in this review in the context ofits onset/progression leading to site-restricted and systemic effects. Moreover, some of the possible strategies and therapies to counteractthe different sources of molecular mediators which lead to the age-related inflammatory phenotype will be presented
Lingua originaleEnglish
pagine (da-a)609-618
Numero di pagine10
RivistaCURRENT PHARMACEUTICAL DESIGN
Volume16
Stato di pubblicazionePublished - 2010

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All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Pharmacology
  • Drug Discovery

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