Age-related Diseases: Key Role of Insulin Resistance for theAssociation Between Type II Diabetes and Alzheimer’s Disease

Risultato della ricerca: Other

Abstract

Background: Alzheimer’s disease (AD) and Type 2 diabetes mellitus (T2DM)present many relationships. Insulin resistance (IR) plays a key role in neuronaldegeneration and death. Reduced energy makes neurons more sensible to oxidationcausing mitochondrial damages. Moreover AD brain has lower insulin utilization,reduced expression of its receptors and of IGF 1 and 2, all necessary for neuronalsurvival and learning and memory processes. Hyperinsulinemia is correlated withincrease of hyerphosphorilated tau-protein. SHIP2, a phosphatase, is an antagonistof PI3K. Since the PI3K plays a key role in the biological effects of insulin, itsattenuation could be associated with IR in T2DM. Methods: We have conducted acase-control study evaluating the association of three SNPs of SHIP2 in T2DM andAD patients and old and young subjects. SNPs study has been developed by ARMSPCR that make it possible to detect a single SNP thanks to the terminal 3’-nucleotideof one of the primers that anneal with target mutation. Results: Significantdifferences were observed for one functional SNP between AD patients and youngsubjects, old and young subjects but not AD patients and old subjects.Conclusions: Our preliminary results seem to suggest a putative correlationbetween this SNP and aging thus strengthening the hypothesis of a closerelationship among AD and diabetes. In fact, to verify this relationship we arecollecting blood from T2DM patients. Moreover we will collect AD samples becauseto confirm these results a bigger cohort needs.
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2012

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