The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64 + 2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.
|Numero di pagine||7|
|Stato di pubblicazione||Published - 2013|
All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis
Vallese, D., Taddeo, A., Di Stefano, A., Vallese, D., Delle Donne, L., Giannuzzi, P., Gnemmi, I., Della Bella, S., Mezzani, A., & Eleuteri, E. (2013). Aerobic training and angiogenesis activation in patients with stable chronic heart failure: a preliminary report. Biomarkers, 18, 418-424.