Abstract
The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64 + 2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.
Lingua originale | English |
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pagine (da-a) | 418-424 |
Numero di pagine | 7 |
Rivista | Biomarkers |
Volume | 18 |
Stato di pubblicazione | Published - 2013 |
All Science Journal Classification (ASJC) codes
- ???subjectarea.asjc.1300.1303???
- ???subjectarea.asjc.1300.1308???
- ???subjectarea.asjc.2300.2307???