ADVANCED ENDOSCOPIC IMAGING FOR SURVEILLANCE FOR DYSPLASIA AND COLORECTAL CANCER IN INFLAMMATORY BOWEL DISEASE: COULD THE PATHOLOGIST BE FURTHER HELPED?

Vincenzo Davide Palumbo, Attilio Ignazio Lo Monte, Giuseppe Damiano, Giovanni Tomasello, Mario Cottone, Salvatore Marasà, Dario Raimondo, Emanuele Sinagra, Marco Messina, Andreas Sturm, Francesca Rossi, Giovanni Tomasello, Tiziana Facella, Attilio I. Lo Monte, Marco Giunta, Gabriele Spinelli

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

Patients with inflammatory bowel disease (IBD) have an increased risk of developing intestinal cancer. The magnitude of that increased risk as well as how best to mitigate it remain a topic of ongoing investigation in the field. It is important to quantify the risk of colorectal cancer in association with IBD. The reported risk varies widely between studies. This is partly due to the different methodologies used in the studies. Because of the limitations of surveillance strategies based on the detection of dysplasia, advanced endoscopic imaging and techniques involving the detection of alterations in mucosal antigens and genetic abnormalities are being investigated. Development of new biomarkers, predicting future occurrence of colonic neoplasia may lead to more biomarker-based surveillance. There are promising results that may lead to more efficient surveillance in IBD patients and more general acceptance of its use. A multidisciplinary approach, involving in particular endoscopists and pathologists, together with a centralized patient management, could help to optimize treatments and follow-up measures, both of which could help to reduce the IBD-associated cancer risk.
Lingua originaleEnglish
pagine (da-a)26-38
Numero di pagine13
RivistaSaudi Journal of Gastroenterology
Volume20
Stato di pubblicazionePublished - 2014

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Inflammatory Bowel Diseases
Colorectal Neoplasms
Biomarkers
Intestinal Neoplasms
Neoplasms
Pathologists
Antigens
Therapeutics

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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ADVANCED ENDOSCOPIC IMAGING FOR SURVEILLANCE FOR DYSPLASIA AND COLORECTAL CANCER IN INFLAMMATORY BOWEL DISEASE: COULD THE PATHOLOGIST BE FURTHER HELPED? / Palumbo, Vincenzo Davide; Lo Monte, Attilio Ignazio; Damiano, Giuseppe; Tomasello, Giovanni; Cottone, Mario; Marasà, Salvatore; Raimondo, Dario; Sinagra, Emanuele; Messina, Marco; Sturm, Andreas; Rossi, Francesca; Tomasello, Giovanni; Facella, Tiziana; Lo Monte, Attilio I.; Giunta, Marco; Spinelli, Gabriele.

In: Saudi Journal of Gastroenterology, Vol. 20, 2014, pag. 26-38.

Risultato della ricerca: Article

Palumbo, VD, Lo Monte, AI, Damiano, G, Tomasello, G, Cottone, M, Marasà, S, Raimondo, D, Sinagra, E, Messina, M, Sturm, A, Rossi, F, Tomasello, G, Facella, T, Lo Monte, AI, Giunta, M & Spinelli, G 2014, 'ADVANCED ENDOSCOPIC IMAGING FOR SURVEILLANCE FOR DYSPLASIA AND COLORECTAL CANCER IN INFLAMMATORY BOWEL DISEASE: COULD THE PATHOLOGIST BE FURTHER HELPED?', Saudi Journal of Gastroenterology, vol. 20, pagg. 26-38.
Palumbo, Vincenzo Davide ; Lo Monte, Attilio Ignazio ; Damiano, Giuseppe ; Tomasello, Giovanni ; Cottone, Mario ; Marasà, Salvatore ; Raimondo, Dario ; Sinagra, Emanuele ; Messina, Marco ; Sturm, Andreas ; Rossi, Francesca ; Tomasello, Giovanni ; Facella, Tiziana ; Lo Monte, Attilio I. ; Giunta, Marco ; Spinelli, Gabriele. / ADVANCED ENDOSCOPIC IMAGING FOR SURVEILLANCE FOR DYSPLASIA AND COLORECTAL CANCER IN INFLAMMATORY BOWEL DISEASE: COULD THE PATHOLOGIST BE FURTHER HELPED?. In: Saudi Journal of Gastroenterology. 2014 ; Vol. 20. pagg. 26-38.
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abstract = "Patients with inflammatory bowel disease (IBD) have an increased risk of developing intestinal cancer. The magnitude of that increased risk as well as how best to mitigate it remain a topic of ongoing investigation in the field. It is important to quantify the risk of colorectal cancer in association with IBD. The reported risk varies widely between studies. This is partly due to the different methodologies used in the studies. Because of the limitations of surveillance strategies based on the detection of dysplasia, advanced endoscopic imaging and techniques involving the detection of alterations in mucosal antigens and genetic abnormalities are being investigated. Development of new biomarkers, predicting future occurrence of colonic neoplasia may lead to more biomarker-based surveillance. There are promising results that may lead to more efficient surveillance in IBD patients and more general acceptance of its use. A multidisciplinary approach, involving in particular endoscopists and pathologists, together with a centralized patient management, could help to optimize treatments and follow-up measures, both of which could help to reduce the IBD-associated cancer risk.",
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AU - Palumbo, Vincenzo Davide

AU - Lo Monte, Attilio Ignazio

AU - Damiano, Giuseppe

AU - Tomasello, Giovanni

AU - Cottone, Mario

AU - Marasà, Salvatore

AU - Raimondo, Dario

AU - Sinagra, Emanuele

AU - Messina, Marco

AU - Sturm, Andreas

AU - Rossi, Francesca

AU - Tomasello, Giovanni

AU - Facella, Tiziana

AU - Lo Monte, Attilio I.

AU - Giunta, Marco

AU - Spinelli, Gabriele

PY - 2014

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AB - Patients with inflammatory bowel disease (IBD) have an increased risk of developing intestinal cancer. The magnitude of that increased risk as well as how best to mitigate it remain a topic of ongoing investigation in the field. It is important to quantify the risk of colorectal cancer in association with IBD. The reported risk varies widely between studies. This is partly due to the different methodologies used in the studies. Because of the limitations of surveillance strategies based on the detection of dysplasia, advanced endoscopic imaging and techniques involving the detection of alterations in mucosal antigens and genetic abnormalities are being investigated. Development of new biomarkers, predicting future occurrence of colonic neoplasia may lead to more biomarker-based surveillance. There are promising results that may lead to more efficient surveillance in IBD patients and more general acceptance of its use. A multidisciplinary approach, involving in particular endoscopists and pathologists, together with a centralized patient management, could help to optimize treatments and follow-up measures, both of which could help to reduce the IBD-associated cancer risk.

UR - http://hdl.handle.net/10447/87103

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EP - 38

JO - Saudi Journal of Gastroenterology

JF - Saudi Journal of Gastroenterology

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