Abstract

During embryonic development, a pool of cells may become a reserve of undifferentiated cells, the embryo-stolen adult stem cells (ESASC). ESASC may be responsible for adult tissue homeostasis, as well as disease development. Transdifferentiation is a sort of reprogramming of ESASC from one germ layer-derived tissue towards another. Transdifferentiation has been described to take place from mesoderm to ectodermal- or endodermal-derived tissues and viceversa but not from ectodermal- to endodermal-derived tissues. We hypothesise that two different populations of ESASC could exist, the first ecto/mesoblast-committed and the second endo/mesoblast-committed. If confirmed, this hypothesis could lead to new studies on the molecular mechanisms of cell differentiation and to a better understanding of the pathogenesis of a number of diseases.
Lingua originaleEnglish
pagine (da-a)83-85
Numero di pagine3
RivistaEUROPEAN JOURNAL OF HISTOCHEMISTRY
Volume51
Stato di pubblicazionePublished - 2007

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Adult Stem Cells
embryo (animal)
Embryonic Structures
Germ Layers
Mesoderm
cell differentiation
Embryonic Development
Cell Differentiation
homeostasis
Homeostasis
embryogenesis
pathogenesis
cells
adult stem cells
tissues
Population

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Histology
  • Biophysics
  • Anatomy
  • Animal Science and Zoology
  • Developmental Biology

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title = "ADULT STEM CELLS: THE REAL ROOT INTO THE EMBRYO?",
abstract = "During embryonic development, a pool of cells may become a reserve of undifferentiated cells, the embryo-stolen adult stem cells (ESASC). ESASC may be responsible for adult tissue homeostasis, as well as disease development. Transdifferentiation is a sort of reprogramming of ESASC from one germ layer-derived tissue towards another. Transdifferentiation has been described to take place from mesoderm to ectodermal- or endodermal-derived tissues and viceversa but not from ectodermal- to endodermal-derived tissues. We hypothesise that two different populations of ESASC could exist, the first ecto/mesoblast-committed and the second endo/mesoblast-committed. If confirmed, this hypothesis could lead to new studies on the molecular mechanisms of cell differentiation and to a better understanding of the pathogenesis of a number of diseases.",
keywords = "stem cell",
author = "Marianna Bellafiore and {La Rocca}, Giampiero and Sabrina David and Felicia Farina and Fabio Bucchieri and Francesco Cappello and {Di Felice}, Valentina and Rita Anzalone and Giovanni Peri and Giovanni Zummo and Antonio Palma",
year = "2007",
language = "English",
volume = "51",
pages = "83--85",
journal = "EUROPEAN JOURNAL OF HISTOCHEMISTRY",
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TY - JOUR

T1 - ADULT STEM CELLS: THE REAL ROOT INTO THE EMBRYO?

AU - Bellafiore, Marianna

AU - La Rocca, Giampiero

AU - David, Sabrina

AU - Farina, Felicia

AU - Bucchieri, Fabio

AU - Cappello, Francesco

AU - Di Felice, Valentina

AU - Anzalone, Rita

AU - Peri, Giovanni

AU - Zummo, Giovanni

AU - Palma, Antonio

PY - 2007

Y1 - 2007

N2 - During embryonic development, a pool of cells may become a reserve of undifferentiated cells, the embryo-stolen adult stem cells (ESASC). ESASC may be responsible for adult tissue homeostasis, as well as disease development. Transdifferentiation is a sort of reprogramming of ESASC from one germ layer-derived tissue towards another. Transdifferentiation has been described to take place from mesoderm to ectodermal- or endodermal-derived tissues and viceversa but not from ectodermal- to endodermal-derived tissues. We hypothesise that two different populations of ESASC could exist, the first ecto/mesoblast-committed and the second endo/mesoblast-committed. If confirmed, this hypothesis could lead to new studies on the molecular mechanisms of cell differentiation and to a better understanding of the pathogenesis of a number of diseases.

AB - During embryonic development, a pool of cells may become a reserve of undifferentiated cells, the embryo-stolen adult stem cells (ESASC). ESASC may be responsible for adult tissue homeostasis, as well as disease development. Transdifferentiation is a sort of reprogramming of ESASC from one germ layer-derived tissue towards another. Transdifferentiation has been described to take place from mesoderm to ectodermal- or endodermal-derived tissues and viceversa but not from ectodermal- to endodermal-derived tissues. We hypothesise that two different populations of ESASC could exist, the first ecto/mesoblast-committed and the second endo/mesoblast-committed. If confirmed, this hypothesis could lead to new studies on the molecular mechanisms of cell differentiation and to a better understanding of the pathogenesis of a number of diseases.

KW - stem cell

UR - http://hdl.handle.net/10447/18187

M3 - Article

VL - 51

SP - 83

EP - 85

JO - EUROPEAN JOURNAL OF HISTOCHEMISTRY

JF - EUROPEAN JOURNAL OF HISTOCHEMISTRY

SN - 1121-760X

ER -