During embryonic development, a pool of cells may become a reserve of undifferentiated cells, the embryo-stolen adult stem cells (ESASC). ESASC may be responsible for adult tissue homeostasis, as well as disease development. Transdifferentiation is a sort of reprogramming of ESASC from one germ layer-derived tissue towards another. Transdifferentiation has been described to take place from mesoderm to ectodermal- or endodermal-derived tissues and viceversa but not from ectodermal- to endodermal-derived tissues. We hypothesise that two different populations of ESASC could exist, the first ecto/mesoblast-committed and the second endo/mesoblast-committed. If confirmed, this hypothesis could lead to new studies on the molecular mechanisms of cell differentiation and to a better understanding of the pathogenesis of a number of diseases.
Lingua originaleEnglish
pagine (da-a)83-85
Numero di pagine3
RivistaEuropean Journal of Histochemistry
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2702???
  • ???subjectarea.asjc.1100.1103???
  • ???subjectarea.asjc.1300.1309???
  • ???subjectarea.asjc.1300.1304???
  • ???subjectarea.asjc.2700.2722???
  • ???subjectarea.asjc.1300.1307???


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