Administration of a Synbiotic to Free-Living Elderly and Evaluation of SerumCytokines. A Pilot Study

Calogero Caruso; Giuseppina Candore; Sonya Vasto; null Marzulli; null Martulli; null Jirillo; null Pugliese; null Amati

Administration of a Synbiotic to Free-Living Elderly and Evaluation of SerumCytokines. A Pilot Study

Calogero Caruso, Giuseppina Candore, Sonya Vasto, Marzulli, Martulli, Jirillo, Pugliese, Amati

Risultato della ricerca: Article › peer review

Abstract

Ten free-living elderly were administered with a synbiotic [fermented milk containing Lactobacillus rhamnosus Gorbach andGoldin (LGG)] and oligofructose as a prebiotic for one month. Serum cytokines were evaluated before (T0) and after (T1) synbioticadministration. At T0, values of Interleukin (IL)-12, IL-6, IL-10, IL-1 and Tumor Necrosis Factor (TNF)- were lower than normalcontrols, with the exception of IL-8, thus confirming previous results on the impairment of both innate and adaptive responses in elderly.At T1, the synbiotic was able to significantly increase, depressed values of IL-1, IL-6 and IL-8 with a trend to a modest increase for therestant cytokines.In conclusion, the synbiotic used in this study seems to be very beneficial to elderly for its capacity to maintain the immune homeostasis,even if an increase in dosage and prolongation of administration time are required for a better modulation of the aged adaptive immuneresponse.

Lingua originale	English
Numero di pagine	5
Rivista	CURRENT PHARMACEUTICAL DESIGN
Volume	16
Stato di pubblicazione	Published - 2010

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

Altri file e collegamenti

OA Link

Fingerprint Entra nei temi di ricerca di 'Administration of a Synbiotic to Free-Living Elderly and Evaluation of SerumCytokines. A Pilot Study'. Insieme formano una fingerprint unica.

Cita questo

@article{f91068a3a7c04b2695d5f464cbf2040b,

title = "Administration of a Synbiotic to Free-Living Elderly and Evaluation of SerumCytokines. A Pilot Study",

abstract = "Ten free-living elderly were administered with a synbiotic [fermented milk containing Lactobacillus rhamnosus Gorbach andGoldin (LGG)] and oligofructose as a prebiotic for one month. Serum cytokines were evaluated before (T0) and after (T1) synbioticadministration. At T0, values of Interleukin (IL)-12, IL-6, IL-10, IL-1 and Tumor Necrosis Factor (TNF)- were lower than normalcontrols, with the exception of IL-8, thus confirming previous results on the impairment of both innate and adaptive responses in elderly.At T1, the synbiotic was able to significantly increase, depressed values of IL-1, IL-6 and IL-8 with a trend to a modest increase for therestant cytokines.In conclusion, the synbiotic used in this study seems to be very beneficial to elderly for its capacity to maintain the immune homeostasis,even if an increase in dosage and prolongation of administration time are required for a better modulation of the aged adaptive immuneresponse.",

author = "Calogero Caruso and Giuseppina Candore and Sonya Vasto and Marzulli and Martulli and Jirillo and Pugliese and Amati",

year = "2010",

language = "English",

volume = "16",

journal = "CURRENT PHARMACEUTICAL DESIGN",

issn = "1381-6128",

}

TY - JOUR

T1 - Administration of a Synbiotic to Free-Living Elderly and Evaluation of SerumCytokines. A Pilot Study

AU - Caruso, Calogero

AU - Candore, Giuseppina

AU - Vasto, Sonya

AU - Marzulli, null

AU - Martulli, null

AU - Jirillo, null

AU - Pugliese, null

AU - Amati, null

PY - 2010

Y1 - 2010

N2 - Ten free-living elderly were administered with a synbiotic [fermented milk containing Lactobacillus rhamnosus Gorbach andGoldin (LGG)] and oligofructose as a prebiotic for one month. Serum cytokines were evaluated before (T0) and after (T1) synbioticadministration. At T0, values of Interleukin (IL)-12, IL-6, IL-10, IL-1 and Tumor Necrosis Factor (TNF)- were lower than normalcontrols, with the exception of IL-8, thus confirming previous results on the impairment of both innate and adaptive responses in elderly.At T1, the synbiotic was able to significantly increase, depressed values of IL-1, IL-6 and IL-8 with a trend to a modest increase for therestant cytokines.In conclusion, the synbiotic used in this study seems to be very beneficial to elderly for its capacity to maintain the immune homeostasis,even if an increase in dosage and prolongation of administration time are required for a better modulation of the aged adaptive immuneresponse.

AB - Ten free-living elderly were administered with a synbiotic [fermented milk containing Lactobacillus rhamnosus Gorbach andGoldin (LGG)] and oligofructose as a prebiotic for one month. Serum cytokines were evaluated before (T0) and after (T1) synbioticadministration. At T0, values of Interleukin (IL)-12, IL-6, IL-10, IL-1 and Tumor Necrosis Factor (TNF)- were lower than normalcontrols, with the exception of IL-8, thus confirming previous results on the impairment of both innate and adaptive responses in elderly.At T1, the synbiotic was able to significantly increase, depressed values of IL-1, IL-6 and IL-8 with a trend to a modest increase for therestant cytokines.In conclusion, the synbiotic used in this study seems to be very beneficial to elderly for its capacity to maintain the immune homeostasis,even if an increase in dosage and prolongation of administration time are required for a better modulation of the aged adaptive immuneresponse.

UR - http://hdl.handle.net/10447/77291

M3 - Article

VL - 16

JO - CURRENT PHARMACEUTICAL DESIGN

JF - CURRENT PHARMACEUTICAL DESIGN

SN - 1381-6128

ER -