Adjuvant denosumab in early breast-cancer

Giuseppina Campisi; Alberto Bedogni; Vittorio Fusco

Adjuvant denosumab in early breast-cancer

Giuseppina Campisi, Alberto Bedogni, Vittorio Fusco

Discipline Chirurgiche, Oncologiche e Stomatologiche

Risultato della ricerca: Article › peer review

Abstract

We read with interest the D-CARE trial report by Robert Coleman and colleagues1 on the adjuvant administration of denosumab in patients with early-stage breast cancer. Despite the negative results, which pose concerns about high dose denosumab schedules in an adjuvant setting, this large and well- designed trial can provide useful clinical data that are usually difficult to obtain from observational studies, particularly regarding medication- related osteonecrosis of the jaw (MRONJ).

Lingua originale	English
pagine (da-a)	e124-
Numero di pagine	1
Rivista	THE LANCET ONCOLOGY
Volume	21
Stato di pubblicazione	Published - 2020

All Science Journal Classification (ASJC) codes

Oncology

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title = "Adjuvant denosumab in early breast-cancer",

abstract = "We read with interest the D-CARE trial report by Robert Coleman and colleagues1 on the adjuvant administration of denosumab in patients with early-stage breast cancer. Despite the negative results, which pose concerns about high dose denosumab schedules in an adjuvant setting, this large and well- designed trial can provide useful clinical data that are usually difficult to obtain from observational studies, particularly regarding medication- related osteonecrosis of the jaw (MRONJ).",

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T1 - Adjuvant denosumab in early breast-cancer

AU - Campisi, Giuseppina

AU - Bedogni, Alberto

AU - Fusco, Vittorio

PY - 2020

Y1 - 2020

N2 - We read with interest the D-CARE trial report by Robert Coleman and colleagues1 on the adjuvant administration of denosumab in patients with early-stage breast cancer. Despite the negative results, which pose concerns about high dose denosumab schedules in an adjuvant setting, this large and well- designed trial can provide useful clinical data that are usually difficult to obtain from observational studies, particularly regarding medication- related osteonecrosis of the jaw (MRONJ).

AB - We read with interest the D-CARE trial report by Robert Coleman and colleagues1 on the adjuvant administration of denosumab in patients with early-stage breast cancer. Despite the negative results, which pose concerns about high dose denosumab schedules in an adjuvant setting, this large and well- designed trial can provide useful clinical data that are usually difficult to obtain from observational studies, particularly regarding medication- related osteonecrosis of the jaw (MRONJ).

UR - http://hdl.handle.net/10447/408720

M3 - Article

VL - 21

SP - e124-

JO - THE LANCET ONCOLOGY

JF - THE LANCET ONCOLOGY

SN - 1470-2045

ER -