Adjuvant Chemoradiation Therapy in Gastric Cancer: Critically Reviewing the Past and Visualizing the Next Step Forward

Antonio Russo, Giuseppe Bronte, Christian Diego Rolfo, Konstantinos Papadimitriou, Christian Rolfo, Panteleimon Kountourakis, Marc Peeters, Vassilios Vassiliou, Konstantinos Papadimitriou, Demetris Papamichael, Georgios Antoniou

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3 Citazioni (Scopus)

Abstract

Gastric cancer remains one of the most common malignancies worldwide. Despite the significant advances in surgical treatment and multimodality strategies, prognosis has modestly improved over the last two decades. Locoregional relapse remains one of the main issues and the combined chemoradiation treatment seems to be one of the preferred approaches. However, more than ten years after the hallmark INT-0116 trial, minimal progress has been made both in terms of effectiveness and toxicity. Moreover, new regimens added to combined therapy failed to prove favourable results. Herein, we attempt a thorough literature review comparing pros and cons of all relative studies and potential bias, targeting well-designed future approaches.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine0
RivistaGastroenterology Research and Practice
Volume2015
Stato di pubblicazionePublished - 2015

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Stomach Neoplasms
Recurrence
Neoplasms
Therapeutics
iodonitrotetrazolium

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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Adjuvant Chemoradiation Therapy in Gastric Cancer: Critically Reviewing the Past and Visualizing the Next Step Forward. / Russo, Antonio; Bronte, Giuseppe; Rolfo, Christian Diego; Papadimitriou, Konstantinos; Rolfo, Christian; Kountourakis, Panteleimon; Peeters, Marc; Vassiliou, Vassilios; Papadimitriou, Konstantinos; Papamichael, Demetris; Antoniou, Georgios.

In: Gastroenterology Research and Practice, Vol. 2015, 2015, pag. -.

Risultato della ricerca: Article

Russo, Antonio ; Bronte, Giuseppe ; Rolfo, Christian Diego ; Papadimitriou, Konstantinos ; Rolfo, Christian ; Kountourakis, Panteleimon ; Peeters, Marc ; Vassiliou, Vassilios ; Papadimitriou, Konstantinos ; Papamichael, Demetris ; Antoniou, Georgios. / Adjuvant Chemoradiation Therapy in Gastric Cancer: Critically Reviewing the Past and Visualizing the Next Step Forward. In: Gastroenterology Research and Practice. 2015 ; Vol. 2015. pagg. -.
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AU - Russo, Antonio

AU - Bronte, Giuseppe

AU - Rolfo, Christian Diego

AU - Papadimitriou, Konstantinos

AU - Rolfo, Christian

AU - Kountourakis, Panteleimon

AU - Peeters, Marc

AU - Vassiliou, Vassilios

AU - Papadimitriou, Konstantinos

AU - Papamichael, Demetris

AU - Antoniou, Georgios

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N2 - Gastric cancer remains one of the most common malignancies worldwide. Despite the significant advances in surgical treatment and multimodality strategies, prognosis has modestly improved over the last two decades. Locoregional relapse remains one of the main issues and the combined chemoradiation treatment seems to be one of the preferred approaches. However, more than ten years after the hallmark INT-0116 trial, minimal progress has been made both in terms of effectiveness and toxicity. Moreover, new regimens added to combined therapy failed to prove favourable results. Herein, we attempt a thorough literature review comparing pros and cons of all relative studies and potential bias, targeting well-designed future approaches.

AB - Gastric cancer remains one of the most common malignancies worldwide. Despite the significant advances in surgical treatment and multimodality strategies, prognosis has modestly improved over the last two decades. Locoregional relapse remains one of the main issues and the combined chemoradiation treatment seems to be one of the preferred approaches. However, more than ten years after the hallmark INT-0116 trial, minimal progress has been made both in terms of effectiveness and toxicity. Moreover, new regimens added to combined therapy failed to prove favourable results. Herein, we attempt a thorough literature review comparing pros and cons of all relative studies and potential bias, targeting well-designed future approaches.

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