Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS)

Carla Giordano, Piernicola Garofalo, Carla Giordano, Cavallo, Guzzetti, Centonze, Michele Sacco, Filippo De Luca, De Luca, Pesce, Caruso-Nicoletti, De Luca, Salerno, Greggio, Orlando, Angeletti, Centonze, Tafi, Bernasconi, Di PietroCianfarani, Parpagnoli, Licenziati, Della Casa, Caruso-Nicoletti, Antoniazzi, Mohamad Maghnie, Cardinale, Citro, Cianfarani, Sandro Loche, Luca Persani, Sergio Bernasconi

Risultato della ricerca: Articlepeer review

4 Citazioni (Scopus)

Abstract

Background: With the use of non-objective measurement, adherence to growth hormone (GH) therapy has been reported suboptimal in a large proportion of patients, and poor adherence has been shown to affect short-term growth response in patients receiving GH treatment. Objective: The Easypod™ electronic device allows objective measurement of adherence. In this study, we report 3-year prospective adherence data of the Italian cohort of naïve GH deficient (GHD) children extrapolated from the Easypod Connect Observational Study (ECOS) database. Patients and methods: Seventy-three GHD children naïve to GH treatment were included in the analysis. 22 Italian centers participated in the study. Results: Mean adherence rate was consistently above 85% across the 3-year observation period. Particularly, mean adherence was 88.5%, 86.6%, and 85.7% after 1, 2 and 3 years, respectively. Mean (± SD) height-SDS increase after the first year was 0.41 (± 0.38). Conclusions: The majority of naïve GHD children starting GH treatment with Easypod maintained an adherence rate > 85% up to 3 years. Easypod is a useful tool to follow-up patients’ adherence allowing timely intervention to improve optimal treatment for these patients.
Lingua originaleEnglish
Numero di pagine4
RivistaJournal of Endocrinological Investigation
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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