Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS)

Carla Giordano, Piernicola Garofalo, Carla Giordano, Cavallo, Guzzetti, Centonze, Michele Sacco, Salerno, Orlando, Filippo De Luca, De Luca, Pesce, Caruso-Nicoletti, De Luca, Salerno, Greggio, Orlando, Angeletti, Centonze, TafiPersani, Bernasconi, Di Pietro, Di Pietro, Cianfarani, De Luca, Centonze, Parpagnoli, Licenziati, Della Casa, Caruso-Nicoletti, Antoniazzi, Mohamad Maghnie, Cardinale, Citro, Cianfarani, Sandro Loche, Luca Persani, Di Pietro, Sergio Bernasconi

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)

Abstract

Background: With the use of non-objective measurement, adherence to growth hormone (GH) therapy has been reported suboptimal in a large proportion of patients, and poor adherence has been shown to affect short-term growth response in patients receiving GH treatment. Objective: The Easypod™ electronic device allows objective measurement of adherence. In this study, we report 3-year prospective adherence data of the Italian cohort of naïve GH deficient (GHD) children extrapolated from the Easypod Connect Observational Study (ECOS) database. Patients and methods: Seventy-three GHD children naïve to GH treatment were included in the analysis. 22 Italian centers participated in the study. Results: Mean adherence rate was consistently above 85% across the 3-year observation period. Particularly, mean adherence was 88.5%, 86.6%, and 85.7% after 1, 2 and 3 years, respectively. Mean (± SD) height-SDS increase after the first year was 0.41 (± 0.38). Conclusions: The majority of naïve GHD children starting GH treatment with Easypod maintained an adherence rate > 85% up to 3 years. Easypod is a useful tool to follow-up patients’ adherence allowing timely intervention to improve optimal treatment for these patients.
Lingua originaleEnglish
Numero di pagine4
RivistaJournal of Endocrinological Investigation
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1310???

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