Abstract

Activin A, is a multifunctional cytokine of the transforming growth factor-b superfamily of growth factors. This molecule has been shown to be implicated in the regulation of a broad range of important biological functions including bone remodelling. Therefore, a deregulation in the activin signalling pathway may result in disturbances of normal bone metabolism and, eventually, in the onset of severe pathological conditions associated with an altered bone resorption. These observations support the concept that Act A might also be implicated in the pathogenesis of bone metastasis. This review provides insight into the most recent advances in understanding the role of this growth factor in the pathogenesis of bone metastasis, and discusses the implications related to the biomedical applications of these findings. J. Cell. Physiol. 225: 302–309, 2010. 2010 Wiley-Liss, Inc.
Lingua originaleEnglish
pagine (da-a)302-309
Numero di pagine8
RivistaJournal of Cellular Physiology
Volume225
Stato di pubblicazionePublished - 2010

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Bone
Neoplasm Metastasis
Bone and Bones
Activins
Bone Remodeling
Transforming Growth Factors
Bone Resorption
Intercellular Signaling Peptides and Proteins
Cytokines
Metabolism
Growth
activin A
Molecules

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Cell Biology
  • Clinical Biochemistry
  • Physiology

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Activin A and bone metastasis. / Leto, Gaetano.

In: Journal of Cellular Physiology, Vol. 225, 2010, pag. 302-309.

Risultato della ricerca: Article

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AB - Activin A, is a multifunctional cytokine of the transforming growth factor-b superfamily of growth factors. This molecule has been shown to be implicated in the regulation of a broad range of important biological functions including bone remodelling. Therefore, a deregulation in the activin signalling pathway may result in disturbances of normal bone metabolism and, eventually, in the onset of severe pathological conditions associated with an altered bone resorption. These observations support the concept that Act A might also be implicated in the pathogenesis of bone metastasis. This review provides insight into the most recent advances in understanding the role of this growth factor in the pathogenesis of bone metastasis, and discusses the implications related to the biomedical applications of these findings. J. Cell. Physiol. 225: 302–309, 2010. 2010 Wiley-Liss, Inc.

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