The acid-catalyzed cyclization of mono epoxides of cnicin acetonide (3) was investigated. Several 6,12-eudesmanolides wereobtained, and their stereochemistry established by extensive spectroscopic analyses. Chemical correlations also led to theassignment of the absolute configuration of 1β,10α-epoxy-salonitenolide (13), a previously isolated natural product. Thecytotoxic activities of some compounds were determined against A549 and MCF-7 tumor cell lines. The esterifiedgermacranolides 2–6 were selectively cytotoxic against the MCF-7 breast cancer cell line.
|Numero di pagine||6|
|Rivista||Natural Product Communications|
|Stato di pubblicazione||Published - 2010|
All Science Journal Classification (ASJC) codes
- Plant Science
- Drug Discovery
- Complementary and alternative medicine