Abstract
The acid-catalyzed cyclization of mono epoxides of cnicin acetonide (3) was investigated. Several 6,12-eudesmanolides wereobtained, and their stereochemistry established by extensive spectroscopic analyses. Chemical correlations also led to theassignment of the absolute configuration of 1β,10α-epoxy-salonitenolide (13), a previously isolated natural product. Thecytotoxic activities of some compounds were determined against A549 and MCF-7 tumor cell lines. The esterifiedgermacranolides 2–6 were selectively cytotoxic against the MCF-7 breast cancer cell line.
| Lingua originale | English |
|---|---|
| pagine (da-a) | 675-680 |
| Numero di pagine | 6 |
| Rivista | Natural Product Communications |
| Volume | 5 |
| Stato di pubblicazione | Published - 2010 |
All Science Journal Classification (ASJC) codes
- ???subjectarea.asjc.3000.3004???
- ???subjectarea.asjc.1100.1110???
- ???subjectarea.asjc.3000.3002???
- ???subjectarea.asjc.2700.2707???