Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia: A systematic review and meta-analysis

Nicola Veronese, Patricia Schofield, Grazia D'Onofrio, Enzo Manzato, Marco Volpe, Pinar Soysal, Nicola Veronese, Claudio Luchini, Brendon Stubbs, Marco Solmi, Ahmet Turan Isik, Giuseppe Sergi, Alberto Pilotto

Risultato della ricerca: Articlepeer review

20 Citazioni (Scopus)

Abstract

We conducted a systematic review and meta-analysis investigating the influence of acetylcholinesterase inhibitors (AChEIs) therapy on nutritional status and weight across observational and interventional studies. Two authors searched major electronic databases from inception until 10/14/2015 for longitudinal, open-label and randomised double-blind placebo controlled (randomised controlled trials (RCTs)) studies of AChEIs in patients with dementia reporting nutritional status outcome data. Out of 3551 initial hits, 25 studies (12 open-label trials, 9 RCTs and 4 longitudinal studies) including 10 792 patients with dementia were meta-analysed. In longitudinal studies (median follow-up 6 months), a significant cumulative incidence of weight loss between baseline and follow-up evaluation was observed (studies=2; 5%; 95% CI 1% to 34%, p<0.0001; I2 =95%). These findings were confirmed in open-label trials (6%; 95% CI 4% to 7%, p<0.0001; I2 =78%). In 9 RCTs (median follow-up 5 months), those taking AChEIs more frequently experienced weight loss than participants taking placebo (OR=2.18; 95% CI 1.50 to 3.17, p<0.0001; I2 =29%). AChEIs therapy contributes to weight loss in patients with dementia, with a 2-fold increased risk observed in the meta-analysis of RCTs. Clinicians should carefully consider the benefit and risk of prescribing AChEIs. Nutritional status should be routinely evaluated in patients with dementia treated with AChEIs. © 2016 Published by the BMJ Publishing Group Limited.
Lingua originaleEnglish
pagine (da-a)1368-1374
Numero di pagine7
RivistaJournal of Neurology, Neurosurgery and Psychiatry
Volume87
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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