Abstract

Acetaldehyde contributes to alcohol’s neuroactive effects through its own motivational properties. This chapter gathers current evidence on acetaldehyde psychoactive action, focusing on behavioral investigations able to unveil acetaldehyde rewarding effects and their pharmacological modulation in vivo.Acetaldehyde induces conditioned place preference for paired environment and cues and is dose-dependently self-administered in a two-bottle choice drinking paradigm. Acetaldehyde’s motivational properties are further highlighted by operant paradigms tailored to model several addiction-like behaviors, such as induction and maintenance of operant responding, drug-seeking in extinction, relapse following deprivation, and resistance to punishment. Acetaldehyde-related behaviors are sensitive to pharmacological manipulations of dopamine and endocannabinoid signaling, two systems that functionally interplay in controlling motivation. This evidence holds promising potential for the development of novel pharmacological approaches aimed at reducing alcohol abuse.
Lingua originaleEnglish
Titolo della pubblicazione ospiteNeuroscience of Alcohol
Pagine345-353
Numero di pagine9
Stato di pubblicazionePublished - 2019

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All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Cita questo

Brancato, A., & Cannizzaro, C. (2019). Acetaldehyde and Motivation. In Neuroscience of Alcohol (pagg. 345-353)