Abnormal mitotic spindle assembly and cytokinesis induced by D-Limonene in cultured mammalian cells

Risultato della ricerca: Article

11 Citazioni (Scopus)

Abstract

d-Limonene is found widely in citrus and many other plant species; it is a major constituent of many essential oils and is used as a solvent for commercial purposes. With the discovery of its chemotherapeutic properties against cancer, it is important to investigate the biological effects of the exposure to d-Limonene and elucidate its, as yet unknown, mechanism of action. We reported here that d-Limonene is toxic in V79 Chinese hamster cells in a dose-dependent manner. Moreover, to determine the cellular target of d-Limonene, we performed morphological observations and immunocytochemical analysis and we showed that this drug has a direct effect on dividing cells preventing assembly of mitotic spindle microtubules. This affects both chromosome segregation and cytokinesis, resulting in aneuploidy that in turn can lead to cell death or genomic instability.
Lingua originaleEnglish
pagine (da-a)1-5
Numero di pagine5
RivistaMutagenesis
VolumeLuglio 2013
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Genetics
  • Toxicology
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis

Fingerprint Entra nei temi di ricerca di 'Abnormal mitotic spindle assembly and cytokinesis induced by D-Limonene in cultured mammalian cells'. Insieme formano una fingerprint unica.

  • Cita questo