Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells

Giuseppe Montalto, Melchiorre Cervello, Weifeng Mao, Alberto M. Martelli, Saverio Candido, Stefano Ratti, Agnieszka Gizak, Kvin Lertpiriyapong, Dariusz Rakus, Pedro L. Rosalen, Massimo Libra, Linda S. Steelman, James A. Mccubrey, Paolo Lombardi, Ramiro M. Murata, Lucio Cocco, Giuseppe Montalto, Matilde Y. Follo, Stephen L. Abrams

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

Berberine (BBR) is a common nutraceutical consumed by millions worldwide. BBR has many different effects on human health, e.g., diabetes, diarrhea, inflammation and now more recently it has been proposed to have potent anti-cancer effects. BBR has been shown to suppress the growth of cancer cells more than normal cells. BBR has been proposed to exert its growth-inhibitory effects by many different biochemical mechanisms including: suppression of cell cycle progression, induction of reactive oxygen species, induction of apoptosis and autophagy and interactions with DNA potentially leading to DNA damage, and altered gene expression. Pancreatic cancer is a leading cancer worldwide associated with a poor prognosis. As our population ages, pancreatic cancer has an increasing incidence and will likely become the second leading cause of death from cancer. There are few truly-effective therapeutic options for pancreatic cancer. Surgery and certain chemotherapeutic drugs are used to treat pancreatic cancer patients. Novel approaches to treat pancreatic cancer patients are direly needed as they usually survive for less than a year after being diagnosed. In the following manuscript, we discuss the abilities of BBR and certain chemically-modified BBRs (NAX compounds) to suppress growth of pancreatic cancer cells.
Lingua originaleEnglish
pagine (da-a)172-182
Numero di pagine11
RivistaDefault journal
Volume71
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Cancer Research

Cita questo

Montalto, G., Cervello, M., Mao, W., Martelli, A. M., Candido, S., Ratti, S., ... Abrams, S. L. (2019). Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells. Default journal, 71, 172-182.

Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells. / Montalto, Giuseppe; Cervello, Melchiorre; Mao, Weifeng; Martelli, Alberto M.; Candido, Saverio; Ratti, Stefano; Gizak, Agnieszka; Lertpiriyapong, Kvin; Rakus, Dariusz; Rosalen, Pedro L.; Libra, Massimo; Steelman, Linda S.; Mccubrey, James A.; Lombardi, Paolo; Murata, Ramiro M.; Cocco, Lucio; Montalto, Giuseppe; Follo, Matilde Y.; Abrams, Stephen L.

In: Default journal, Vol. 71, 2019, pag. 172-182.

Risultato della ricerca: Article

Montalto, G, Cervello, M, Mao, W, Martelli, AM, Candido, S, Ratti, S, Gizak, A, Lertpiriyapong, K, Rakus, D, Rosalen, PL, Libra, M, Steelman, LS, Mccubrey, JA, Lombardi, P, Murata, RM, Cocco, L, Montalto, G, Follo, MY & Abrams, SL 2019, 'Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells', Default journal, vol. 71, pagg. 172-182.
Montalto, Giuseppe ; Cervello, Melchiorre ; Mao, Weifeng ; Martelli, Alberto M. ; Candido, Saverio ; Ratti, Stefano ; Gizak, Agnieszka ; Lertpiriyapong, Kvin ; Rakus, Dariusz ; Rosalen, Pedro L. ; Libra, Massimo ; Steelman, Linda S. ; Mccubrey, James A. ; Lombardi, Paolo ; Murata, Ramiro M. ; Cocco, Lucio ; Montalto, Giuseppe ; Follo, Matilde Y. ; Abrams, Stephen L. / Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells. In: Default journal. 2019 ; Vol. 71. pagg. 172-182.
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abstract = "Berberine (BBR) is a common nutraceutical consumed by millions worldwide. BBR has many different effects on human health, e.g., diabetes, diarrhea, inflammation and now more recently it has been proposed to have potent anti-cancer effects. BBR has been shown to suppress the growth of cancer cells more than normal cells. BBR has been proposed to exert its growth-inhibitory effects by many different biochemical mechanisms including: suppression of cell cycle progression, induction of reactive oxygen species, induction of apoptosis and autophagy and interactions with DNA potentially leading to DNA damage, and altered gene expression. Pancreatic cancer is a leading cancer worldwide associated with a poor prognosis. As our population ages, pancreatic cancer has an increasing incidence and will likely become the second leading cause of death from cancer. There are few truly-effective therapeutic options for pancreatic cancer. Surgery and certain chemotherapeutic drugs are used to treat pancreatic cancer patients. Novel approaches to treat pancreatic cancer patients are direly needed as they usually survive for less than a year after being diagnosed. In the following manuscript, we discuss the abilities of BBR and certain chemically-modified BBRs (NAX compounds) to suppress growth of pancreatic cancer cells.",
author = "Giuseppe Montalto and Melchiorre Cervello and Weifeng Mao and Martelli, {Alberto M.} and Saverio Candido and Stefano Ratti and Agnieszka Gizak and Kvin Lertpiriyapong and Dariusz Rakus and Rosalen, {Pedro L.} and Massimo Libra and Steelman, {Linda S.} and Mccubrey, {James A.} and Paolo Lombardi and Murata, {Ramiro M.} and Lucio Cocco and Giuseppe Montalto and Follo, {Matilde Y.} and Abrams, {Stephen L.}",
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T1 - Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells

AU - Montalto, Giuseppe

AU - Cervello, Melchiorre

AU - Mao, Weifeng

AU - Martelli, Alberto M.

AU - Candido, Saverio

AU - Ratti, Stefano

AU - Gizak, Agnieszka

AU - Lertpiriyapong, Kvin

AU - Rakus, Dariusz

AU - Rosalen, Pedro L.

AU - Libra, Massimo

AU - Steelman, Linda S.

AU - Mccubrey, James A.

AU - Lombardi, Paolo

AU - Murata, Ramiro M.

AU - Cocco, Lucio

AU - Montalto, Giuseppe

AU - Follo, Matilde Y.

AU - Abrams, Stephen L.

PY - 2019

Y1 - 2019

N2 - Berberine (BBR) is a common nutraceutical consumed by millions worldwide. BBR has many different effects on human health, e.g., diabetes, diarrhea, inflammation and now more recently it has been proposed to have potent anti-cancer effects. BBR has been shown to suppress the growth of cancer cells more than normal cells. BBR has been proposed to exert its growth-inhibitory effects by many different biochemical mechanisms including: suppression of cell cycle progression, induction of reactive oxygen species, induction of apoptosis and autophagy and interactions with DNA potentially leading to DNA damage, and altered gene expression. Pancreatic cancer is a leading cancer worldwide associated with a poor prognosis. As our population ages, pancreatic cancer has an increasing incidence and will likely become the second leading cause of death from cancer. There are few truly-effective therapeutic options for pancreatic cancer. Surgery and certain chemotherapeutic drugs are used to treat pancreatic cancer patients. Novel approaches to treat pancreatic cancer patients are direly needed as they usually survive for less than a year after being diagnosed. In the following manuscript, we discuss the abilities of BBR and certain chemically-modified BBRs (NAX compounds) to suppress growth of pancreatic cancer cells.

AB - Berberine (BBR) is a common nutraceutical consumed by millions worldwide. BBR has many different effects on human health, e.g., diabetes, diarrhea, inflammation and now more recently it has been proposed to have potent anti-cancer effects. BBR has been shown to suppress the growth of cancer cells more than normal cells. BBR has been proposed to exert its growth-inhibitory effects by many different biochemical mechanisms including: suppression of cell cycle progression, induction of reactive oxygen species, induction of apoptosis and autophagy and interactions with DNA potentially leading to DNA damage, and altered gene expression. Pancreatic cancer is a leading cancer worldwide associated with a poor prognosis. As our population ages, pancreatic cancer has an increasing incidence and will likely become the second leading cause of death from cancer. There are few truly-effective therapeutic options for pancreatic cancer. Surgery and certain chemotherapeutic drugs are used to treat pancreatic cancer patients. Novel approaches to treat pancreatic cancer patients are direly needed as they usually survive for less than a year after being diagnosed. In the following manuscript, we discuss the abilities of BBR and certain chemically-modified BBRs (NAX compounds) to suppress growth of pancreatic cancer cells.

UR - http://hdl.handle.net/10447/357819

M3 - Article

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